Evidence map›Paper›PMID 21933915›Full record

ArticlemBio2011

A gastric pathogen moves chemotaxis in a new direction.

Emily Goers Sweeney, Karen Guillemin

Abstract readComment
In one paragraph

Article in mBio, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Emily Goers SweeneyInstitute of Molecular Biology, University of Oregon, Eugene, Oregon, USA.
Karen Guillemin

Funding

Molecular and genetic analysis of the hielcobacter pylori virulence Factor CagAR01DK075667 · NIDDK · UNIVERSITY OF OREGON · PI GUILLEMIN, KAREN J · 2007 to 2010
$1.1M
Mechanistic Investigations of Helicobacter pylori ChemotaxisF32AI091098 · NIAID · UNIVERSITY OF OREGON · PI SWEENEY, EMILY SARAH MARIE · 2010 to 2012
$153k
NIAID NIH HHS F32 AI091098NIDDK NIH HHS R01 DK075667
6 · The paper itself

Abstract

For almost 50 years, Escherichia coli has been the model for understanding how bacteria orient their movement in response to chemical cues, but recent studies of chemotaxis in other bacteria have revealed interesting variations from prevailing paradigms. Investigating the human pathogen Helicobacter pylori, Amieva and colleagues [mBio 2(4):e00098-11, 2011] discovered a new chemotaxis regulator, ChePep, which modulates swimming behavior through the canonical histidine-aspartate phosphorelay system. Functionally conserved among the epsilonproteobacteria, ChePep is essential for H. pylori to navigate deep into the stomach's gastric glands and may be an attractive target for novel antibiotics.

Indexed as

ChemotaxisAnimalsBacterial ProteinsEpsilonproteobacteriaFemaleGastric MucosaVirulence FactorsBacterial ProteinsVirulence Factors

Identifiers

PMID21933915
PMCPMC3171985

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.