ArticleBMC microbiology2011
Clonal diversity of the glutamate dehydrogenase gene in Giardia duodenalis from Thai isolates: evidence of genetic exchange or mixed infections?
Article in BMC microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Molecular detection and genetic characterization ofFrontiers in parasitology · 2026Article
- Prevalence of intestinal parasites with molecular detection and identification ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Detection of enteric parasites and molecular characterization ofParasitology · 2021Article
- Multilocus Genotyping ofPathogens (Basel, Switzerland) · 2021Article
- Molecular diversity of Giardia duodenalis in children under 5 years from the Manhiça district, Southern Mozambique enrolled in a matched case-control study on the aetiology of diarrhoea.PLoS neglected tropical diseases · 2021Article
- Multilocus genotyping of Giardia duodenalis in Southwestern Iran. A community survey.PloS one · 2020Article
- Genetic Diversity of the Flavohemoprotein Gene ofInfection and drug resistance · 2020Article
- Clone-based haplotyping of Giardia intestinalis assemblage B human isolates.Parasitology research · 2019Article
- Local and global genetic diversity of protozoan parasites: Spatial distribution of Cryptosporidium and Giardia genotypes.PLoS neglected tropical diseases · 2017Observational
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- Population expansion and gene flow in Giardia duodenalis as revealed by triosephosphate isomerase gene.Parasites & vectors · 2015Article
- Molecular epidemiology of giardiasis among Orang Asli in Malaysia: application of the triosephosphate isomerase gene.BMC infectious diseases · 2014Article
- Multilocus characterization and phylogenetic analysis of Leishmania siamensis isolated from autochthonous visceral leishmaniasis cases, southern Thailand.BMC microbiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe glutamate dehydrogenase gene (gdh) is one of the most popular and useful genetic markers for the genotypic analysis of Giardia duodenalis (syn. G. lamblia, G. intestinalis), the protozoan that widely causes enteric disease in humans. To determine the distribution of genotypes of G. duodenalis in Thai populations and to investigate the extent of sequence variation at this locus, 42 fecal samples were collected from 3 regions of Thailand i.e., Central, Northern, and Eastern regions. All specimens were analyzed using PCR-based genotyping and recombinant subcloning methods.
resultsThe results showed that the prevalence of assemblages A and B among these populations was approximately equal, 20 (47.6%) and 22 (52.4%), respectively. Sequence analysis revealed that the nucleotide diversity of assemblage B was significantly greater than that in assemblage A. Among all assemblage B positive specimens, the allelic sequence divergence within isolates was detected. Nine isolates showed mixed alleles, ranged from three to nine distinct alleles per isolate. Statistical analysis demonstrated the occurrence of genetic recombination within subassemblages BIII and BIV was likely.
conclusionThis study supports increasing evidence that G. duodenalis has the potential for genetic exchange.
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