Trial reportMicrocirculation (New York, N.Y. : 1994)2011
Retinal microvascular changes and the risk of developing obesity: population-based cohort study.
Trial report in Microcirculation (New York, N.Y. : 1994), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Relationship Between Retinal Vascular Measurements and Anthropometric Indices in Patients Diagnosed with Persistent COVID-19.Journal of clinical medicine · 2025Article
- Retinal microvascular associations with cardiometabolic risk factors differ by diabetes status: results from the UK Biobank.Diabetologia · 2022Article
- The Role of Systemic Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction.Biomolecules · 2022Review
- Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response.World journal of diabetes · 2021Review
- The Relation between Body Mass Index and Retinal Photoreceptor Morphology and Microvascular Changes Measured with Adaptive Optics (rtx1) High-Resolution Imaging.Journal of ophthalmology · 2021Article
- Retinal Vascular Tortuosity and Diameter Associations with Adiposity and Components of Body Composition.Obesity (Silver Spring, Md.) · 2020Article
- Effects of bariatric surgery on retinal microvascular architecture in obese patients.International journal of obesity (2005) · 2019Article
- Assessing Microvascular Function in Humans from a Chronic Disease Perspective.Journal of the American Society of Nephrology : JASN · 2017Review
- Is there any connection between choroidal thickness and obesity?Therapeutic advances in ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundRecent studies have hypothesized that endothelial and microvascular dysfunction may play a role in the development of obesity. Previous studies have shown that retinal microvascular changes are associated with diabetes, hypertension, and cardiovascular disease. In contrast, few prospective studies have examined the association between retinal microvascular changes and the risk of developing obesity.
methodsWe examined n = 2089 nonobese subjects from a population-based cohort in Beaver Dam, Wisconsin (aged 44-85 years, 49% women). Retinal arteriolar and venular diameters were measured from baseline retinal photographs. The main outcome-of-interest was 15-year incidence of obesity.
resultsRetinal venular widening was positively associated with incident obesity over a 15-year follow-up period. This association was independent of age, gender, smoking, alcohol intake, education, physical activity, body mass index, serum cholesterol, and C-reactive protein levels. Compared with subjects with retinal venular diameter in the lowest tertile (referent), the multivariable relative risk (95% confidence interval) of obesity among subjects in the highest tertile was 1.68 (1.24-2.28); p-trend = 0.0005. In contrast, narrow retinal arterioles were not associated with obesity.
conclusionsIn a population-based cohort, we found that wider retinal venules are positively associated with risk of developing obesity, suggesting a role for microvascular dysfunction in its etiology.
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