ArticleAlcoholism, clinical and experimental research2012
Subjective perceptions associated with the ascending and descending slopes of breath alcohol exposure vary with recent drinking history.
Article in Alcoholism, clinical and experimental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Using naltrexone to validate a human laboratory test system to screen new medications for alcoholism (TESMA)- a randomized clinical trial.Translational psychiatry · 2023Trial
- Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures.Alcoholism, clinical and experimental research · 2019Trial
- Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults.Psychopharmacology · 2015Trial
- Differences in subjective response to alcohol in heavy- and light-drinking Chinese men versus Caucasian American men.Addiction (Abingdon, England) · 2015Trial
- The Self-Rated Effects of Alcohol Are Related to Presystemic Metabolism of Alcohol.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Article
- Binge and high-intensity drinking-Associations with intravenous alcohol self-administration and underlying risk factors.Addiction biology · 2022Article
- To Infuse or Ingest in Human Laboratory Alcohol Research.Alcoholism, clinical and experimental research · 2020Review
- Alcohol Tolerance in Human Laboratory Studies for Development of Medications to treat Alcohol Use Disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2020Review
- Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes.Alcohol (Fayetteville, N.Y.) · 2018Article
- Characterization of hangover following intravenous alcohol exposure in social drinkers: methodological and clinical implications.Addiction biology · 2018Article
- Vulnerability for Alcohol Use Disorder and Rate of Alcohol Consumption.The American journal of psychiatry · 2017Article
- A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence.Addiction biology · 2017Article
- Association between overall rate of change in rising breath alcohol concentration and the magnitude of acute tolerance of subjective intoxication via the Mellanby method.Human psychopharmacology · 2017Article
- Experimental psychopathology paradigms for alcohol use disorders: Applications for translational research.Behaviour research and therapy · 2016Review
- Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking.Alcoholism, clinical and experimental research · 2015Article
- Alcohol exposure rate control through physiologically based pharmacokinetic modeling.Alcoholism, clinical and experimental research · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe differentiator model predicts that individuals with a positive family history of alcoholism (FHA) or heavy alcohol consumers will feel more sensitive to the effects of alcohol on the ascending phase of the blood alcohol content while feeling less sedated on the descending phase. This study tested whether subjective perceptions are sensitive to the slope of breath alcohol concentration (BrAC) and whether that sensitivity is associated with an FHA and/or recent drinking history (RDH).
methodsFamily-history-positive (FHP, n = 27) and family-history-negative (FHN, n = 27) young adult nondependent drinkers were infused intravenously with alcohol in 2 sessions separated by 1 week. After 20 minutes, one session had an ascending BrAC (+3.0 mg%/min), while the other session had a descending BrAC (-1 mg%/min). The BrAC for both sessions at this point was approximately 60 mg%, referred to as the crossover point. Subjective perceptions of intoxication, high, stimulated, and sedation were sampled frequently and then interpolated to the crossover point. Within-subject differences between ascending and descending responses were examined for associations with FHA and/or RDH.
resultsRecent moderate drinkers reported increased perceptions of feeling intoxicated (p < 0.023) and high (p < 0.023) on the ascending slope compared with the descending slope. In contrast, recent light drinkers felt more intoxicated and high on the descending slope.
conclusionsSubjective perceptions in young adult social drinkers depend on the slope of the BrAC when examined in association with RDH. These results support the differentiator model hypothesis concerning the ascending slope and suggest that moderate alcohol consumers could be at risk for increased alcohol consumption because they feel more intoxicated and high on the ascending slope. Subjects did not feel less sedated on the descending slope, contrary to the differentiator model but replicating several previous studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.