ArticleACS chemical biology2011
Attenuation of virulence in pathogenic bacteria using synthetic quorum-sensing modulators under native conditions on plant hosts.
Article in ACS chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Quorum Sensing Behavior in the Model Unicellular EukaryoteiScience · 2020Article
- Selection of Appropriate Autoinducer Analogues for the Modulation of Quorum Sensing at the Host-Bacterium Interface.ACS chemical biology · 2018Article
- Non-native autoinducer analogs capable of modulating the SdiA quorum sensing receptor inBeilstein journal of organic chemistry · 2018Article
- Biocontrol of the Potato Blackleg and Soft Rot Diseases Caused by Dickeya dianthicola.Applied and environmental microbiology · 2016Article
- Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa.Chembiochem : a European journal of chemical biology · 2015Article
- Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing inACS biomaterials science & engineering · 2015Article
- Silencing the mob: disrupting quorum sensing as a means to fight plant disease.Molecular plant pathology · 2015Review
- Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR.Organic & biomolecular chemistry · 2015Article
- Plant responses to bacterial N-acyl L-homoserine lactones are dependent on enzymatic degradation to L-homoserine.ACS chemical biology · 2014Article
- Non-native acylated homoserine lactones reveal that LuxIR quorum sensing promotes symbiont stability.Environmental microbiology · 2014Article
- Non-native N-aroyl L-homoserine lactones are potent modulators of the quorum sensing receptor RpaR in Rhodopseudomonas palustris.Chembiochem : a European journal of chemical biology · 2014Article
- N,N'-alkylated Imidazolium-derivatives act as quorum-sensing inhibitors targeting the Pectobacterium atrosepticum-induced symptoms on potato tubers.International journal of molecular sciences · 2013Article
- Exploiting quorum sensing to confuse bacterial pathogens.Microbiology and molecular biology reviews : MMBR · 2013Review
- Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators.Organic & biomolecular chemistry · 2013Article
- Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones.ACS chemical biology · 2012Article
- Chemical methods to interrogate bacterial quorum sensing pathways.Organic & biomolecular chemistry · 2012Article
- 2-Aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms.Angewandte Chemie (International ed. in English) · 2012Article
- Efficient biostimulation of native and introduced quorum-quenching Rhodococcus erythropolis populations is revealed by a combination of analytical chemistry, microbiology, and pyrosequencing.Applied and environmental microbiology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Quorum sensing (QS) is often critical in both pathogenic and mutualistic relationships between bacteria and their eukaryotic hosts. Gram-negative bacteria typically use N-acylated l-homoserine lactone (AHL) signals for QS. We have identified a number of synthetic AHL analogues that are able to strongly modulate QS in culture-based, reporter gene assays. While informative, these assays represent idealized systems, and their relevance to QS under native conditions is often unclear. As one of our goals is to utilize synthetic QS modulators to study bacterial communication under native conditions, identifying robust host-bacteria model systems for their evaluation is crucial. We reasoned that the host-pathogen interaction between Solanum tuberosum (potato) and the Gram-negative pathogen Pectobacterium carotovora would be ideal for such studies as we have identified several potent, synthetic QS modulators for this pathogen, and infection assays in potato are facile. Herein, we report on our development of this host-pathogen system, and another in Phaseolus vulgaris (green bean), as a means for monitoring the ability of abiotic AHLs to modulate QS-regulated virulence in host infection assays. Our assays confirmed that QS modulators previously identified through culture-based assays largely retained their activity profiles when introduced into the plant host. However, inhibition of virulence in wild-type infections was highly dependent on the timing of compound dosing. This study is the first to demonstrate that our AHL analogues are active in wild-type bacteria in their native eukaryotic hosts and provides compelling evidence for the application of these molecules as probes to study QS in a range of organisms and environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.