ArticleJournal of neuroscience research2012
Differential gene expression in motor and sensory Schwann cells in the rat femoral nerve.
Article in Journal of neuroscience research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Therapeutical efficacy of nanofibrous polycaprolactone-amniotic membrane loaded with 8% celecoxib in peripheral nerve injury: modulating the PI3K-AKT signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Muscle-derived stem cell exosomes with overexpressed miR-214 promote the regeneration and repair of rat sciatic nerve after crush injury to activate the JAK2/STAT3 pathway by targeting PTEN.Frontiers in molecular neuroscience · 2023Article
- Peripheral glia diversity.Journal of anatomy · 2022Review
- Robo2 Drives Target-Selective Peripheral Nerve Regeneration in Response to Glia-Derived Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- [Research progress of peripheral nerve mismatch regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021Review
- Review
- Gene expression and growth factor analysis in early nerve regeneration following segmental nerve defect reconstruction with a mesenchymal stromal cell-enhanced decellularized nerve allograft.Plastic and reconstructive surgery. Global open · 2020Article
- Protein biomarkers of neural system.Journal of otology · 2019Review
- Spatiotemporal Differences in Gene Expression Between Motor and Sensory Autografts and Their Effect on Femoral Nerve Regeneration in the Rat.Frontiers in cellular neuroscience · 2019Article
- Comparative transcriptomic profiling of peripheral efferent and afferent nerve fibres at different developmental stages in mice.Scientific reports · 2018Article
- Differential Gene Expression in Primary Cultured Sensory and Motor Nerve Fibroblasts.Frontiers in neuroscience · 2018Article
- Biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application.Scientific reports · 2017Article
- Preferential Enhancement of Sensory and Motor Axon Regeneration by Combining Extracellular Matrix Components with Neurotrophic Factors.International journal of molecular sciences · 2016Article
- Repair, protection and regeneration of peripheral nerve injury.Neural regeneration research · 2015Article
- Femoral nerve regeneration and its accuracy under different injury mechanisms.Neural regeneration research · 2015Article
- Pathways regulating modality-specific axonal regeneration in peripheral nerve.Experimental neurology · 2015Review
- GDNF preconditioning can overcome Schwann cell phenotypic memory.Experimental neurology · 2015Article
- Update in facial nerve paralysis: tissue engineering and new technologies.Current opinion in otolaryngology & head and neck surgery · 2014Review
- Rapid assessment of migration and proliferation: a novel 3D high-throughput platform for rational and combinatorial screening of tissue-specific biomaterials.Tissue engineering. Part C, Methods · 2014Article
- Glial cell line-derived neurotrophic factor promotes increased phenotypic marker expression in femoral sensory and motor-derived Schwann cell cultures.Experimental neurology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Phenotypic differences in Schwann cells (SCs) may help to guide axonal regeneration down motor or sensory specific pathways following peripheral nerve injury. The goal of this study was to identify phenotypic markers for SCs harvested from the cutaneous (sensory) and quadriceps (motor) branches of the rat femoral nerve and to study the effects of expansion culture on the expression patterns of these motor or sensory phenotypic markers. RNA was extracted from SCs harvested from the motor and sensory branches of the rat femoral nerve and analyzed using Affymetrix Gene Chips (Rat Genome 230 v2.0 Array A). Genes that were upregulated in motor SCs compared with the sensory SCs or vice versa were identified, and the results were verified for a subset of genes using quantitative real-time polymerase chain reaction (qRT-PCR). The expression levels of the "phenotype-specific" genes were then evaluated in SC expansion cultures at various time points over 30 days by qRT-PCR to determine the effect of expansion on SC phenotype. Expression levels of the phenotype-specific genes were significantly altered after expansion culture for both the motor and the sensory markers compared with fresh nerve tissue. These results indicate that both motor and sensory SC gene expression patterns are disrupted during expansion in vitro and may affect the ability of SCs to express phenotype-specific genes after transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.