Trial reportDiabetologia2011
Human enterovirus infections in children at increased risk for type 1 diabetes: the Babydiet study.
Trial report in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The virome in early life and childhood and development of islet autoimmunity and type 1 diabetes: A systematic review and meta-analysis of observational studies.Reviews in medical virology · 2021Pooled it
- Coding-complete genome sequence and phylogenetic analysis of Coxsackievirus B3 isolated from South Korea.Microbiology resource announcements · 2024Article
- Antiviral Mechanisms of Saucerneol fromViruses · 2023Article
- Respiratory infections and type 1 diabetes: Potential roles in pathogenesis.Reviews in medical virology · 2023Review
- Review
- Whole-genome analysis of coxsackievirus B3 reflects its genetic diversity in China and worldwide.Virology journal · 2022Article
- Viruses and Type 1 Diabetes: From Enteroviruses to the Virome.Microorganisms · 2021Review
- Prospective virome analyses in young children at increased genetic risk for type 1 diabetes.Nature medicine · 2019Article
- Extending Classification Algorithms to Case-Control Studies.Biomedical engineering and computational biology · 2019Article
- Enteroviral Infections as a Trigger for Type 1 Diabetes.Current diabetes reports · 2018Review
- Molecular epidemiology of enteroviruses in young children at increased risk of type 1 diabetes.PloS one · 2018Article
- Early life origin of type 1 diabetes.Seminars in immunopathology · 2017Review
- Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.Diabetologia · 2017Article
- Beta-cell Specific Autoantibodies: Are they Just an Indicator of Type 1 Diabetes?Current diabetes reviews · 2017Review
- Enterovirus and type 1 diabetes: What is the matter?World journal of diabetes · 2015Review
- Saffold Virus, a Human Cardiovirus, and Risk of Persistent Islet Autoantibodies in the Longitudinal Birth Cohort Study MIDIA.PloS one · 2015Article
- Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes.Diabetologia · 2013Article
- Viral infections and molecular mimicry in type 1 diabetes.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2012Review
- Enterovirus infection in Korean children and anti-enteroviral potential candidate agents.Korean journal of pediatrics · 2012Article
- Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe aim of this study was to examine human enteroviruses (HEVs) and other intestinal viruses derived from children who participated in the Babydiet intervention study and to analyse the findings according to the appearance of islet autoantibodies, dietary intervention, maternal type 1 diabetes and clinical symptoms.
methodsIn the Babydiet study the influence of first gluten exposure (6 or 12 months) on the development of islet autoimmunity was investigated in 150 children with increased genetic and familial risk for type 1 diabetes. Blood and stool samples were collected at 3 monthly intervals until the age of 3 years and yearly thereafter. Infections and clinical symptoms were recorded daily for the first year. In the present study, 339 stool samples collected from 104 children during the first year of life were analysed for HEVs and a certain proportion of the samples were analysed for other intestinal viruses.
resultsHEV was detected in 32 (9.4%) samples from 24 (23.1%) children. Altogether 13 serotypes were identified, with HEV-A species being the most common. Children with gastrointestinal symptoms had norovirus (3/11) and sapovirus (1/11) infections in addition to HEV (1/11). Of the 104 children, 22 developed islet autoantibodies. HEV infections were detected in 18% (4/22) and 24% (20/82) of islet-autoantibody-positive and -negative children, respectively (p = 0.5). The prevalence of HEV was similar in the gluten-exposed groups and in children from mothers with type 1 diabetes or from affected fathers and/or siblings (p = 1.0 and 0.6, respectively). CONCLUSIONS/
interpretationNo correlation was found between the presence of HEV in the first year of life and the development of islet autoantibodies. There was no association between HEV infections and dietary intervention, maternal diabetes or clinical symptoms.
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