ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2012
Demographic, dietary, and serum factors and parathyroid hormone in the National Health and Nutrition Examination Survey.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 56 citations in OpenAlex.
- Physical Performance and Vitamin D in Elderly Black Women-The PODA Randomized Clinical Trial.The Journal of clinical endocrinology and metabolism · 2019Trial
- The relationship of Physical performance and Osteoporosis prevention with vitamin D in older African Americans (PODA).Contemporary clinical trials · 2018Trial
- Vitamin D, parathyroid hormone and metabolic syndrome - the PORMETS study.BMC endocrine disorders · 2017Trial
- Investigation of secondary hyperparathyroidism and its contributing factors in hemodialysis patients: A cross-sectional study.Journal of education and health promotion · 2026Article
- Association between serum vitamin A and bone mineral density in adolescents.Scientific reports · 2025Article
- Uric Acid Correlates with Serum Levels of Mineral Bone Metabolism and Inflammation Biomarkers in Patients with Stage 3a-5 Chronic Kidney Disease.Medicina (Kaunas, Lithuania) · 2024Article
- Obesity, diabetes and risk of bone fragility: How BMAT behavior is affected by metabolic disturbances and its influence on bone health.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Review
- Age-specific Reference Intervals of Abbott Intact PTH-Potential Impacts on Clinical Care.Journal of the Endocrine Society · 2024Article
- Machine Learning-Based Prediction of Elevated PTH Levels Among the US General Population.The Journal of clinical endocrinology and metabolism · 2022Article
- Article
- The circadian rhythm of calcium and bone homeostasis in Maasai.American journal of human biology : the official journal of the Human Biology Council · 2022Article
- Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels.International journal of molecular sciences · 2021Review
- Associations of serum vitamins levels with bone mineral density in the different race-ethnicities US adults.BMC musculoskeletal disorders · 2021Article
- Article
- Effects of PTH and PTH Hypersecretion on Bone: a Clinical Perspective.Current osteoporosis reports · 2020Review
- Association between serum uric acid and bone health in adolescents.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Indirect Reference Intervals: Harnessing the Power of Stored Laboratory Data.The Clinical biochemist. Reviews · 2019Review
- Prevalence and treatment of gout among patients with chronic kidney disease in the Irish health system: A national study.PloS one · 2019Article
- Nutrition in Cardioskeletal Health.Advances in nutrition (Bethesda, Md.) · 2016Review
- PTH and Vitamin D.Comprehensive Physiology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledMany determinants of parathyroid hormone (PTH) are unknown. In the National Health and Nutrition Examination Survey (NHANES), numerous factors not classically associated with calcium-phosphorus homeostasis, such as uric acid and smoking, are independently associated with PTH in adults without chronic kidney disease. Associations between serum phosphorus and PTH may vary by race.
introductionAlthough PTH may be an important biomarker for osteoporosis and cardiovascular disease, many determinants of PTH are unknown. We investigated associations between demographic, dietary, and serum factors and PTH level.
methodsWe studied 4,026 white, 1,792 black, and 1,834 Mexican-American adult participants without chronic kidney disease from the 2003-2004 and 2005-2006 NHANES.
resultsThe mean serum PTH level was 38.3 pg/ml for whites, 42.6 pg/ml for blacks, and 41.3 pg/ml for Mexican-Americans. After adjusting for diet, body mass index, serum levels of calcium, phosphorus, 25-hydroxyvitamin D, creatinine, and other factors, smokers compared to non-smokers had lower PTH, ranging from -4.2 pg/ml (95% confidence interval (CI) -7.3 to -1.1) in Mexican-Americans to -6.1 pg/ml (95% CI -8.7 to -3.5) in blacks. After multivariate adjustment, PTH was higher in females compared to males, ranging from 1.1 pg/ml (95% CI -1.2 to 3.4) in Mexican-Americans to 4.5 pg/ml (95% CI 1.9 to 7.0) in blacks, and in older (>60 years) compared to younger participants (<30 years), ranging from 3.7 pg/ml (95% CI 1.3 to 6.1) in Mexican-Americans to 8.0 pg/ml (95% CI 5.4 to 10.7) in blacks. Higher uric acid was associated with higher PTH. In whites only, lower serum phosphorus and lower serum retinol were associated with higher PTH.
conclusionsNumerous factors not classically associated with calcium-phosphorus homeostasis are independently associated with PTH and should be considered in future studies of PTH and chronic disease. Additional research is needed to elucidate mechanisms underlying identified associations with PTH and to explore possible racial differences in phosphorus handling.
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