ArticleEuropean journal of applied physiology2012
Effects of graded exercise-induced dehydration and rehydration on circulatory markers of oxidative stress across the resting and exercising human leg.
Article in European journal of applied physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- Oxidative Stress Assessment in Response to Ultraendurance Exercise: Thiols Redox Status and ROS Production according to Duration of a Competitive Race.Oxidative medicine and cellular longevity · 2016Trial
- Trial
- Chronic low water intake is associated with altered exercise-induced oxidative stress and immune cell responses: a cross-sectional study.Journal of the International Society of Sports Nutrition · 2025Article
- Ex vivo LPS-stimulated cytokine production is associated with hydration status in community-dwelling middle-to-older-aged adults.European journal of nutrition · 2023Article
- Corticospinal and peripheral responses to heat-induced hypo-hydration: potential physiological mechanisms and implications for neuromuscular function.European journal of applied physiology · 2022Review
- Review
- The Impact of Dehydration and Hyperthermia on Circulatory Glutathione Metabolism after Exercise in the Heat with Insights into the Role of Erythrocytes.Life (Basel, Switzerland) · 2021Article
- The Effects of Dehydration on Metabolic and Neuromuscular Functionality During Cycling.International journal of environmental research and public health · 2020Article
- Hydration Status and Cardiovascular Function.Nutrients · 2019Review
- Osmolality Selectively Offsets the Impact of Hyperthermia on Mouse Skeletal MuscleFrontiers in physiology · 2018Article
- Fluid replacement modulates oxidative stress- but not nitric oxide-mediated cutaneous vasodilation and sweating during prolonged exercise in the heat.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- High intensity interval training in the heat enhances exercise-induced lipid peroxidation, but prevents protein oxidation in physically active men.Temperature (Austin, Tex.)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise in the heat enhances oxidative stress markers in the human circulation, but the contribution of active skeletal muscle and the influence of hydration status remain unknown. To address this question, we measured leg exchange of glutathione (GSH), glutathione disulfide (GSSG), superoxide dismutase activity (SOD) and isoprostanes in seven males at rest and during submaximal one-legged knee extensor exercise in the following four conditions: (1) control euhydration (0% reduction in body mass), (2) mild-dehydration (2%), (3) moderate-dehydration (3.5%), (4) rehydration (0%). In all resting and control exercise conditions, a net GSH uptake was observed across the leg. In contrast, a significant leg release of GSH into the circulation (-354 ± 221 μmol/min, P < 0.05) was observed during exercise with moderate-dehydration, which was still present following full rehydration (-206 ± 122 μmol/min, P < 0.05). During exercise, mild and moderate-dehydration decreased both femoral venous erythrocyte SOD activity (195 ± 6 vs. 180 ± 5 U/L, P < 0.05) and plasma isoprostanes (30 ± 1.1 vs. 25.9 ± 1.3 pg/L, P < 0.05), but during rehydration these were not different from control. In conclusion, these findings suggest that active skeletal muscles release GSH into the circulation under moderate dehydration and subsequent rehydration, possibly to enhance the antioxidant defense.
Indexed as
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Registered trials
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