ArticleSkeletal radiology2012
Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging.
Article in Skeletal radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- T2* cartilage mapping in early axial spondyloarthritis: diagnostic accuracy and correlation with clinical characteristics, sacroiliitis MRI scorings, and diffusion metrics.European radiology · 2025Article
- Insights into the Age Dependency of Compositional MR Biomarkers Quantifying the Health Status of Cartilage in Metacarpophalangeal Joints.Diagnostics (Basel, Switzerland) · 2023Article
- MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T.Osteoarthritis and cartilage · 2020Article
- Pre-contrast T1 and cartilage thickness as confounding factors in dGEMRIC when evaluating human cartilage adaptation to physical activity.BMC medical imaging · 2019Article
- Cartilage and bone damage in rheumatoid arthritis.Reumatologia · 2018Review
- Racial differences in biochemical knee cartilage composition between African-American and Caucasian-American women with 3 T MR-based T2 relaxation time measurements--data from the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2015Article
- Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative.Annals of the rheumatic diseases · 2015Article
- Intra-individual assessment of inflammatory severity and cartilage composition of finger joints in rheumatoid arthritis.Skeletal radiology · 2015Article
- T2* mapping for articular cartilage assessment: principles, current applications, and future prospects.Skeletal radiology · 2014Review
- Heading toward a modern imaging approach in juvenile idiopathic arthritis.Current rheumatology reports · 2014Review
- Spectrum of T2* values in knee joint cartilage at 3 T: a cross-sectional analysis in asymptomatic young adult volunteers.Skeletal radiology · 2014Article
- Insights into rheumatoid arthritis from use of MRI.Current rheumatology reports · 2014Review
- Disc degeneration assessed by quantitative T2* (T2 star) correlated with functional lumbar mechanics.Spine · 2013Article
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Authors and funding
17 authors.
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Abstract
purposeTo prospectively evaluate four non-invasive markers of cartilage quality--T2* mapping, native T1 mapping, dGEMRIC and ΔR1--in healthy volunteers and rheumatoid arthritis (RA) patients. MATERIALS AND
methodsCartilage of metacarpophalangeal (MCP) joints II were imaged in 28 consecutive subjects: 12 healthy volunteers [9 women, mean (SD) age 52.67 (9.75) years, range 30-66] and 16 RA patients with MCP II involvement [12 women, mean (SD) age 58.06 (12.88) years, range 35-76]. Sagittal T2* mapping was performed with a multi-echo gradient-echo on a 3 T MRI scanner. For T1 mapping the dual flip angle method was applied prior to native T1 mapping and 40 min after gadolinium application (delayed gadolinium-enhanced MRI of cartilage, dGEMRIC, T1(Gd)). The difference in the longitudinal relaxation rate induced by gadolinium (ΔR1) was calculated. The area under the receiver operating characteristic curve (AROC) was used to test for differentiation of RA patients from healthy volunteers.
resultsdGEMRIC (AUC 0.81) and ΔR1 (AUC 0.75) significantly differentiated RA patients from controls. T2* mapping (AUC 0.66) and native T1 mapping (AUC 0.66) were not significantly different in RA patients compared to controls.
conclusionsThe data support the use of dGEMRIC for the assessment of MCP joint cartilage quality in RA. T2* and native T1 mapping are of low diagnostic value. Pre-contrast T1 mapping for the calculation of ΔR1 does not increase the diagnostic value of dGEMRIC.
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