ArticlePLoS neglected tropical diseases2011
Phylogeography and molecular epidemiology of Yersinia pestis in Madagascar.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- A field-deployable high-resolution SNP genotyping platform for rapid surveillance ofVirulence · 2026Article
- Genetic Diversity and Spatial Distribution ofMicroorganisms · 2026Article
- Evaluating the early diversification of Yersinia pestis and its phylogeographic expansion over 96 years of evolution in Madagascar.Communications biology · 2025Article
- Review of genotyping methods for Yersinia pestis in Madagascar.PLoS neglected tropical diseases · 2024Review
- Multiple Introductions of Yersinia pestis during Urban Pneumonic Plague Epidemic, Madagascar, 2017.Emerging infectious diseases · 2024Article
- Immunogenetics, sylvatic plague and its vectors: insights from the pathogen reservoir Mastomys natalensis in Tanzania.Immunogenetics · 2023Article
- Phylogenetic analysis of the origin and spread of plague in Madagascar.PLoS neglected tropical diseases · 2023Article
- Genetic source tracking of human plague cases in Inner Mongolia-Beijing, 2019.PLoS neglected tropical diseases · 2021Article
- Approaches and perspectives for online learning during the COVID-19 pandemic and future chaos.Journal of education and health promotion · 2021Article
- Human plague: An old scourge that needs new answers.PLoS neglected tropical diseases · 2020Review
- A Survey of Antimicrobial Resistance Determinants in Category A Select Agents, Exempt Strains, and Near-Neighbor Species.International journal of molecular sciences · 2020Article
- Trends of Human Plague, Madagascar, 1998-2016.Emerging infectious diseases · 2019Article
- Article
- Isotopic evidence for niche partitioning and the influence of anthropogenic disturbance on endemic and introduced rodents in central Madagascar.Die Naturwissenschaften · 2018Article
- Variant site strain typer (VaST): efficient strain typing using a minimal number of variant genomic sites.BMC bioinformatics · 2018Article
- Genetic diversity and spatial-temporal distribution of Yersinia pestis in Qinghai Plateau, China.PLoS neglected tropical diseases · 2018Article
- Ten years of surveillance of the Yulong plague focus in China and the molecular typing and source tracing of the isolates.PLoS neglected tropical diseases · 2018Article
- Madagascar can build stronger health systems to fight plague and prevent the next epidemic.PLoS neglected tropical diseases · 2018Article
- Low cost, low tech SNP genotyping tools for resource-limited areas: Plague in Madagascar as a model.PLoS neglected tropical diseases · 2017Article
- Dynamics of the pneumonic plague epidemic in Madagascar, August to October 2017.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
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14 authors.
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Abstract
backgroundPlague was introduced to Madagascar in 1898 and continues to be a significant human health problem. It exists mainly in the central highlands, but in the 1990s was reintroduced to the port city of Mahajanga, where it caused extensive human outbreaks. Despite its prevalence, the phylogeography and molecular epidemiology of Y. pestis in Madagascar has been difficult to study due to the great genetic similarity among isolates. We examine island-wide geographic-genetic patterns based upon whole-genome discovery of SNPs, SNP genotyping and hypervariable variable-number tandem repeat (VNTR) loci to gain insight into the maintenance and spread of Y. pestis in Madagascar. METHODOLOGY/PRINCIPAL
findingsWe analyzed a set of 262 Malagasy isolates using a set of 56 SNPs and a 43-locus multi-locus VNTR analysis (MLVA) system. We then analyzed the geographic distribution of the subclades and identified patterns related to the maintenance and spread of plague in Madagascar. We find relatively high levels of VNTR diversity in addition to several SNP differences. We identify two major groups, Groups I and II, which are subsequently divided into 11 and 4 subclades, respectively. Y. pestis appears to be maintained in several geographically separate subpopulations. There is also evidence for multiple long distance transfers of Y. pestis, likely human mediated. Such transfers have resulted in the reintroduction and establishment of plague in the port city of Mahajanga, where there is evidence for multiple transfers both from and to the central highlands. CONCLUSIONS/SIGNIFICANCE: The maintenance and spread of Y. pestis in Madagascar is a dynamic and highly active process that relies on the natural cycle between the primary host, the black rat, and its flea vectors as well as human activity.
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