ArticlePLoS neglected tropical diseases2011
Amebiasis in HIV-1-infected Japanese men: clinical features and response to therapy.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Antiamoebic drugs for treating amoebic colitis.The Cochrane database of systematic reviews · 2019Pooled it
- Epidemiology, pathology, diagnosis, and management of amoebic liver abscesses in Sub-Saharan Africa: a retrospective cross-sectional study.Annals of medicine and surgery (2012) · 2026Article
- Article
- The history of entamoebiasis.Parasitology · 2025Review
- Immunogenicity and safety of anHuman vaccines & immunotherapeutics · 2024Article
- Amebiasis as a sexually transmitted infection: A re-emerging health problem in developed countries.Global health & medicine · 2023Review
- Injection drug use and sexually transmitted infections among men who have sex with men: A retrospective cohort study at an HIV/AIDS referral hospital in Tokyo, 2013-2022.Epidemiology and infection · 2023Article
- Clinical Features and Gut Microbiome of Asymptomatic Entamoeba histolytica Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Utility of the Rapid Antigen Detection Test E. histolytica Quik Chek for the Diagnosis of Entamoeba histolytica Infection in Nonendemic Situations.Journal of clinical microbiology · 2020Article
- Ongoing transmission of Entamoeba histolytica among newly diagnosed people living with HIV in Taiwan, 2009-2018.PLoS neglected tropical diseases · 2020Article
- Two cases of endoscopically diagnosed amebic colitis treated with paromomycin monotherapy.PLoS neglected tropical diseases · 2020Article
- Seroprevalence ofBMJ open · 2020Article
- Case Report: Acute Amebic Colitis Triggered by Colonoscopy: Exacerbation of Asymptomatic Chronic Infection withThe American journal of tropical medicine and hygiene · 2019Article
- Case Report: Lower Gastrointestinal Bleeding due toThe American journal of tropical medicine and hygiene · 2019Review
- Significance of amebiasis: 10 reasons why neglecting amebiasis might come back to bite us in the gut.PLoS neglected tropical diseases · 2019Article
- A Review of the Global Burden, New Diagnostics, and Current Therapeutics for Amebiasis.Open forum infectious diseases · 2018Review
- Discovery of Antiamebic Compounds That Inhibit Cysteine Synthase From the Enteric Parasitic ProtistFrontiers in cellular and infection microbiology · 2018Article
- Underestimated Amoebic Appendicitis among HIV-1-Infected Individuals in Japan.Journal of clinical microbiology · 2017Article
- Epidemiology of Domestically Acquired Amebiasis in Japan, 2000-2013.The American journal of tropical medicine and hygiene · 2016Article
- Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica.Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasive amebic diseases caused by Entamoeba histolytica are increasing among men who have sex with men and co-infection of ameba and HIV-1 is an emerging problem in developed East Asian countries. To characterize the clinical and epidemiological features of invasive amebiasis in HIV-1 patients, the medical records of 170 co-infected cases were analyzed retrospectively, and E. histolytica genotype was assayed in 14 cases. In this series of HIV-1-infected patients, clinical presentation of invasive amebiasis was similar to that described in the normal host. High fever, leukocytosis and high CRP were associated with extraluminal amebic diseases. Two cases died from amebic colitis (resulting in intestinal perforation in one and gastrointestinal bleeding in one), and three cases died from causes unrelated to amebiasis. Treatment with metronidazole or tinidazole was successful in the other 165 cases. Luminal treatment was provided to 83 patients following metronidazole or tinidazole treatment. However, amebiasis recurred in 6 of these, a frequency similar to that seen in patients who did not receive luminal treatment. Recurrence was more frequent in HCV-antibody positive individuals and those who acquired syphilis during the follow-up period. Various genotypes of E. histolytica were identified in 14 patients but there was no correlation between genotype and clinical features. The outcome of metronidazole and tinidazole treatment of uncomplicated amebiasis was excellent even in HIV-1-infected individuals. Luminal treatment following metronidazole or tinidazole treatment does not reduce recurrence of amebiasis in high risk populations probably due to amebic re-infection.
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