ArticlePloS one2011
Analysis of VEGF--a regulated gene expression in endothelial cells to identify genes linked to angiogenesis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Fibronectin mediates APOE4-driven blood-brain barrier dysfunction in Alzheimer's disease.Nature aging · 2026Article
- Hypoxia induces inflammatory microenvironment by priming specific macrophage polarization and modifies LSC behaviour via VEGF-HIF1α signalling.Translational pediatrics · 2021Article
- ETS factors are required but not sufficient for specific patterns of enhancer activity in different endothelial subtypes.Developmental biology · 2021Article
- Absence of HTATIP2 Expression in A549 Lung Adenocarcinoma Cells Promotes Tumor Plasticity in Response to Hypoxic Stress.Cancers · 2020Article
- Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice.Bone · 2019Article
- Possible cooption of a VEGF-driven tubulogenesis program for biomineralization in echinoderms.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Multiplatform molecular profiling identifies potentially targetable biomarkers in malignant phyllodes tumors of the breast.Oncotarget · 2016Article
- Acetylbritannilactone Modulates Vascular Endothelial Growth Factor Signaling and Regulates Angiogenesis in Endothelial Cells.PloS one · 2016Article
- VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration.Biology open · 2015Article
- VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions.Molecular biology of the cell · 2014Article
- A systems biology view of blood vessel growth and remodelling.Journal of cellular and molecular medicine · 2014Review
- Angiogenesis interactome and time course microarray data reveal the distinct activation patterns in endothelial cells.PloS one · 2014Article
- The transcription factor MEF2C negatively controls angiogenic sprouting of endothelial cells depending on oxygen.PloS one · 2014Article
- Constructing the angiome: a global angiogenesis protein interaction network.Physiological genomics · 2012Article
- Inhibition of ARNT severely compromises endothelial cell viability and function in response to moderate hypoxia.Angiogenesis · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Angiogenesis is important for many physiological processes, diseases, and also regenerative medicine. Therapies that inhibit the vascular endothelial growth factor (VEGF) pathway have been used in the clinic for cancer and macular degeneration. In cancer applications, these treatments suffer from a "tumor escape phenomenon" where alternative pathways are upregulated and angiogenesis continues. The redundancy of angiogenesis regulation indicates the need for additional studies and new drug targets. We aimed to (i) identify novel and missing angiogenesis annotations and (ii) verify their significance to angiogenesis. To achieve these goals, we integrated the human interactome with known angiogenesis-annotated proteins to identify a set of 202 angiogenesis-associated proteins. Across endothelial cell lines, we found that a significant fraction of these proteins had highly perturbed gene expression during angiogenesis. After treatment with VEGF-A, we found increasing expression of HIF-1α, APP, HIV-1 tat interactive protein 2, and MEF2C, while endoglin, liprin β1 and HIF-2α had decreasing expression across three endothelial cell lines. The analysis showed differential regulation of HIF-1α and HIF-2α. The data also provided additional evidence for the role of endothelial cells in Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.