ArticlePloS one2011
Increased expression of cannabinoid CB₁ receptors in Achilles tendinosis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Proteomics perspectives in rotator cuff research: a systematic review of gene expression and protein composition in human tendinopathy.PloS one · 2015Pooled it
- The peripheral neuronal phenotype is important in the pathogenesis of painful human tendinopathy: a systematic review.Clinical orthopaedics and related research · 2013Pooled it
- Novel insights into the pathogenesis of tendon injury: mechanotransduction and neuroplasticity.Neural regeneration research · 2022Article
- Review
- Monoacylglycerol lipase - a target for drug development?British journal of pharmacology · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe endogenous cannabinoid system is involved in the control of pain. However, little is known as to the integrity of the cannabinoid system in human pain syndromes. Here we investigate the expression of the cannabinoid receptor 1 (CB₁) in human Achilles tendons from healthy volunteers and from patients with Achilles tendinosis. METHODOLOGY: Cannabinoid CB₁ receptor immunoreactivity (CB₁IR) was evaluated in formalin-fixed biopsies from individuals suffering from painful Achilles tendinosis in comparison with healthy human Achilles tendons. PRINCIPAL
findingsCB₁IR was seen as a granular pattern in the tenocytes. CB₁IR was also observed in the blood vessel wall and in the perineurium of the nerve. Quantification of the immunoreactivity in tenocytes showed an increase of CB₁ receptor expression in tendinosis tissue compared to control tissue.
conclusionExpression of cannabinoid receptor 1 is increased in human Achilles tendinosis suggesting that the cannabinoid system may be dysregulated in this disorder.
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Registered trials
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