ArticlePloS one2011
AtHKT1;1 mediates nernstian sodium channel transport properties in Arabidopsis root stelar cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- A Salt-ResponsiveInternational journal of molecular sciences · 2026Article
- Chloride-Transporting OsHKT1;1 Splice Variants and Their Expression Profiles Under Salinity Stress in Rice.International journal of molecular sciences · 2026Article
- Deciphering the Sodium Sensing Mechanisms in Glycophytes and Halophytes.Plant, cell & environment · 2025Review
- Identification of the High-Affinity Potassium Transporter Gene Family in Perennial Ryegrass (Genes · 2025Article
- Genomic approaches to enhance adaptive plasticity to cope with soil constraints amidst climate change in wheat.The plant genome · 2024Review
- A Novel High-Affinity Potassium TransporterPlants (Basel, Switzerland) · 2022Article
- Understanding the Integrated Pathways and Mechanisms of Transporters, Protein Kinases, and Transcription Factors in Plants under Salt Stress.International journal of genomics · 2021Review
- Ion Homeostasis and Metabolome Analysis ofFrontiers in plant science · 2021Article
- Mechanisms of Plant Responses and Adaptation to Soil Salinity.Innovation (Cambridge (Mass.)) · 2020Review
- Sodium Influx and Potassium Efflux Currents in Sunflower Root Cells Under High Salinity.Frontiers in plant science · 2020Article
- Expression and Ion Transport Activity of RicePlants (Basel, Switzerland) · 2019Article
- ThePlants (Basel, Switzerland) · 2019Article
- Progress in Understanding the Physiological and Molecular Responses ofInternational journal of molecular sciences · 2019Review
- A Comprehensive Biophysical Model of Ion and Water Transport in Plant Roots. II. Clarifying the Roles of SOS1 in the Salt-Stress Response inFrontiers in plant science · 2019Article
- Pumpkin CmHKT1;1 Controls Shoot Na⁺ Accumulation via Limiting Na⁺ Transport from Rootstock to Scion in Grafted Cucumber.International journal of molecular sciences · 2018Article
- Humic Acid Confers HIGH-AFFINITY K+ TRANSPORTER 1-Mediated Salinity Stress Tolerance in Arabidopsis.Molecules and cells · 2017Article
- Skewing in Arabidopsis roots involves disparate environmental signaling pathways.BMC plant biology · 2017Article
- An Insight into microRNA156 Role in Salinity Stress Responses of Alfalfa.Frontiers in plant science · 2017Article
- A Single Amino-Acid Substitution in the Sodium Transporter HKT1 Associated with Plant Salt Tolerance.Plant physiology · 2016Article
- OsHKT1;4-mediated Na(+) transport in stems contributes to Na(+) exclusion from leaf blades of rice at the reproductive growth stage upon salt stress.BMC plant biology · 2016Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
The Arabidopsis AtHKT1;1 protein was identified as a sodium (Na⁺) transporter by heterologous expression in Xenopus laevis oocytes and Saccharomyces cerevisiae. However, direct comparative in vivo electrophysiological analyses of a plant HKT transporter in wild-type and hkt loss-of-function mutants has not yet been reported and it has been recently argued that heterologous expression systems may alter properties of plant transporters, including HKT transporters. In this report, we analyze several key functions of AtHKT1;1-mediated ion currents in their native root stelar cells, including Na⁺ and K⁺ conductances, AtHKT1;1-mediated outward currents, and shifts in reversal potentials in the presence of defined intracellular and extracellular salt concentrations. Enhancer trap Arabidopsis plants with GFP-labeled root stelar cells were used to investigate AtHKT1;1-dependent ion transport properties using patch clamp electrophysiology in wild-type and athkt1;1 mutant plants. AtHKT1;1-dependent currents were carried by sodium ions and these currents were not observed in athkt1;1 mutant stelar cells. However, K⁺ currents in wild-type and athkt1;1 root stelar cell protoplasts were indistinguishable correlating with the Na⁺ over K⁺ selectivity of AtHKT1;1-mediated transport. Moreover, AtHKT1;1-mediated currents did not show a strong voltage dependence in vivo. Unexpectedly, removal of extracellular Na⁺ caused a reduction in AtHKT1;1-mediated outward currents in Columbia root stelar cells and Xenopus oocytes, indicating a role for external Na⁺ in regulation of AtHKT1;1 activity. Shifting the NaCl gradient in root stelar cells showed a Nernstian shift in the reversal potential providing biophysical evidence for the model that AtHKT1;1 mediates passive Na⁺ channel transport properties.
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