ArticlePloS one2011
NMDA mediated contextual conditioning changes miRNA expression.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 58 citations in OpenAlex.
- The relationship between social adversity, micro-RNA expression and post-traumatic stress in a prospective, community-based cohort.Nature. Mental health · 2026Article
- Growth-suppressor microRNAs mediate synaptic overgrowth and behavioral deficits in Fragile X mental retardation protein deficiency.iScience · 2024Article
- Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders.Neuronal signaling · 2023Review
- The Expression of miRNAs Involved in Long-Term Memory Formation in the CNS of the MolluskInternational journal of molecular sciences · 2022Article
- MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy.Molecular neurobiology · 2022Review
- AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons.EMBO reports · 2020Article
- A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling.Molecular brain · 2020Article
- MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons.Cellular and molecular neurobiology · 2019Article
- Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy.Scientific reports · 2018Article
- A CREB2-targeting microRNA is required for long-term memory after single-trial learning.Scientific reports · 2018Article
- Interplay between TETs and microRNAs in the adult brain for memory formation.Scientific reports · 2018Article
- Physical exercise as an epigenetic modulator of brain plasticity and cognition.Neuroscience and biobehavioral reviews · 2017Review
- mTOR referees memory and disease through mRNA repression and competition.FEBS letters · 2017Review
- A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory.eLife · 2016Article
- microRNAs Modulate Spatial Memory in the Hippocampus and in the Ventral Striatum in a Region-Specific Manner.Molecular neurobiology · 2016Article
- MicroRNAs: Key Regulators in the Central Nervous System and Their Implication in Neurological Diseases.International journal of molecular sciences · 2016Review
- Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Role of MicroRNA in Governing Synaptic Plasticity.Neural plasticity · 2016Review
- Infralimbic EphB2 Modulates Fear Extinction in Adolescent Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Epigenetic pathways through which experiences become linked with biology.Development and psychopathology · 2015Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
We measured the expression of 187 miRNAs using quantitative real time PCR in the hippocampal CA1 region of contextually conditioned mice and cultured embryonic rat hippocampal neurons after neuronal stimulation with either NMDA or bicuculline. Many of the changes in miRNA expression after these three types of stimulation were similar. Surprisingly, the expression level of half of the 187 measured miRNAs was changed in response to contextual conditioning in an NMDA receptor-dependent manner. Genes that control miRNA biogenesis and components of the RISC also exhibited activity induced expression changes and are likely to contribute to the widespread changes in the miRNA profile. The widespread changes in miRNA expression are consistent with the finding that genes up-regulated by contextual conditioning have longer 3' UTRs and more predicted binding sites for miRNAs. Among the miRNAs that changed their expression after contextual conditioning, several inhibit inhibitors of the mTOR pathway. These findings point to a role for miRNAs in learning and memory that includes mTOR-dependent modulation of protein synthesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.