ArticlePloS one2011
Adult spinal cord radial glia display a unique progenitor phenotype.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Single-cell RNA sequencing reveals NestinScience China. Life sciences · 2022Article
- Role of RGC-32 in multiple sclerosis and neuroinflammation - few answers and many questions.Frontiers in immunology · 2022Review
- Beyond the GFAP-Astrocyte Protein Markers in the Brain.Biomolecules · 2021Review
- RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis.Frontiers in immunology · 2021Article
- RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis.Frontiers in immunology · 2020Article
- Article
- Employing Endogenous NSCs to Promote Recovery of Spinal Cord Injury.Stem cells international · 2019Review
- Neural progenitor cells but not astrocytes respond distally to thoracic spinal cord injury in rat models.Neural regeneration research · 2017Article
- Article
- Purinergic signalling in a latent stem cell niche of the rat spinal cord.Purinergic signalling · 2016Article
- Analysis of spatial-temporal gene expression patterns reveals dynamics and regionalization in developing mouse brain.Scientific reports · 2016Article
- The ependymal region of the adult human spinal cord differs from other species and shows ependymoma-like features.Brain : a journal of neurology · 2015Article
- Change of fate commitment in adult neural progenitor cells subjected to chronic inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Existence of a potential neurogenic system in the adult human brain.Journal of translational medicine · 2014Article
- Fgf2 improves functional recovery-decreasing gliosis and increasing radial glia and neural progenitor cells after spinal cord injury.Brain and behavior · 2014Article
- Epigenetics of neural repair following spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Review
- High-resolution gene expression atlases for adult and developing mouse brain and spinal cord.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- Spatial domains of progenitor-like cells and functional complexity of a stem cell niche in the neonatal rat spinal cord.Stem cells (Dayton, Ohio) · 2012Article
- Endogenous proliferation after spinal cord injury in animal models.Stem cells international · 2012Article
- Nestin- and doublecortin-positive cells reside in adult spinal cord meninges and participate in injury-induced parenchymal reaction.Stem cells (Dayton, Ohio) · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Radial glia (RG) are primarily embryonic neuroglial progenitors that express Brain Lipid Binding Protein (Blbp a.k.a. Fabp7) and Glial Fibrillary Acidic Protein (Gfap). We used these transcripts to demarcate the distribution of spinal cord radial glia (SCRG) and screen for SCRG gene expression in the Allen Spinal Cord Atlas (ASCA). We reveal that neonatal and adult SCRG are anchored in a non-ventricular niche at the spinal cord (SC) pial boundary, and express a "signature" subset of 122 genes, many of which are shared with "classic" neural stem cells (NSCs) of the subventricular zone (SVZ) and SC central canal (CC). A core expressed gene set shared between SCRG and progenitors of the SVZ and CC is particularly enriched in genes associated with human disease. Visualizing SCRG in a Fabp7-EGFP reporter mouse reveals an extensive population of SCRG that extend processes around the SC boundary and inwardly (through) the SC white matter (WM), whose abundance increases in a gradient from cervical to lumbar SC. Confocal analysis of multiple NSC-enriched proteins reveals that postnatal SCRG are a discrete and heterogeneous potential progenitor population that become activated by multiple SC lesions, and that CC progenitors are also more heterogeneous than previously appreciated. Gene ontology analysis highlights potentially unique regulatory pathways that may be further manipulated in SCRG to enhance repair in the context of injury and SC disease.
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