ArticlePloS one2011
Expression of microRNAs in the stem cell niche of the adult mouse incisor.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Revisiting the miR-200 Family: A Clan of Five Siblings with Essential Roles in Development and Disease.Biomolecules · 2022Review
- Signaling Modulation byFrontiers in cell and developmental biology · 2021Article
- New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair.World journal of stem cells · 2020Review
- Signaling Modulations of miR-206-3p in Tooth Morphogenesis.International journal of molecular sciences · 2020Article
- Meeting report: a hard look at the state of enamel research.International journal of oral science · 2017Article
- [Expression and function of microRNAs in enamel development].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017Review
- Identification of differential microRNA expression during tooth morphogenesis in the heterodont dentition of miniature pigs, SusScrofa.BMC developmental biology · 2015Article
- Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells.Stem cell research & therapy · 2015Article
- TBX1 protein interactions and microRNA-96-5p regulation controls cell proliferation during craniofacial and dental development: implications for 22q11.2 deletion syndrome.Human molecular genetics · 2015Article
- Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis.BMC genomics · 2014Article
- A pituitary homeobox 2 (Pitx2):microRNA-200a-3p:β-catenin pathway converts mesenchymal cells to amelogenin-expressing dental epithelial cells.The Journal of biological chemistry · 2014Article
- Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages.Experimental cell research · 2014Review
- On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells.Genesis (New York, N.Y. : 2000) · 2014Review
- Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair.PloS one · 2014Article
- Understanding the role of Tbx1 as a candidate gene for 22q11.2 deletion syndrome.Current allergy and asthma reports · 2013Review
- The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.Development (Cambridge, England) · 2013Article
- Article
- microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells.PloS one · 2012Article
- From molecules to mastication: the development and evolution of teeth.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The mouse incisor is a valuable but under-utilized model organ for studying the behavior of adult stem cells. This remarkable tooth grows continuously throughout the animal's lifetime and houses two distinct epithelial stem cell niches called the labial and lingual cervical loop (laCL and liCL, respectively). These stem cells produce progeny that undergo a series of well-defined differentiation events en route to becoming enamel-producing ameloblasts. During this differentiation process, the progeny move out of the stem cell niche and migrate toward the distal tip of the tooth. Although the molecular pathways involved in tooth development are well documented, little is known about the roles of miRNAs in this process. We used microarray technology to compare the expression of miRNAs in three regions of the adult mouse incisor: the laCL, liCL, and ameloblasts. We identified 26 and 35 differentially expressed miRNAs from laCL/liCL and laCL/ameloblast comparisons, respectively. Out of 10 miRNAs selected for validation by qPCR, all transcripts were confirmed to be differentially expressed. In situ hybridization and target prediction analyses further supported the reliability of our microarray results. These studies point to miRNAs that likely play a role in the renewal and differentiation of adult stem cells during stem cell-fueled incisor growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.