Evidence map›Paper›PMID 21931689›Full record

ArticlePloS one2011

Rare occurrence of methicillin-resistant Staphylococcus aureus CC130 with a novel mecA homologue in humans in Germany.

Christiane Cuny, Franziska Layer, Birgit Strommenger, Wolfgang Witte

Abstract read
In one paragraph

Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed.

  1. Infectious Dermatitis in Companion Animals: A One Health Perspective.Animals : an open access journal from MDPI · 2026
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  5. Molecular epidemiology ofFrontiers in cellular and infection microbiology · 2026
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  9. Antimicrobial-ResistantAntibiotics (Basel, Switzerland) · 2025
    Article
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  15. Molecular characterization of antimicrobial resistance genes ofVeterinary research forum : an international quarterly journal · 2024
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  16. Article
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  18. Article
  19. Article
  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christiane CunyWernigerode Branch, Robert Koch Institute, Wernigerode, Germany.
Franziska Layer
Birgit Strommenger
Wolfgang Witte

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MRSA CC130 containing the mecA homologue mecA(LGA251) were reported from the UK and from Denmark so far from cattle and humans. Here we report on 11 MRSA CC130 among a sample of 12691 isolates of human origin collected from January 2006 until June 2011. MRSA CC130 grew insufficiently on chromogernic agar plates for detection of MRSA; the agglutination test for presence of PBP2a was negative. We designed primers for specific detection of mecA(LGA251) as well as for concomitant detection of both, mec(LGA251) and mecA. As already described, the isolates exhibited spa-types t843, t1736, and t1773. The ccrA homologue indicated the presence SCCmec(XI). When subjected to further characterization by means of a commercially available microarray the isolates were negative for sak chp, and scn, and as expected positive for hla, untruncated hlb, and hld. They furthermore contained edinB, aur, slpA, slpB, slpE. From genes coding for surface and cell wall associated products the ica-operon, cap8, clfA, clfF, ebpS, fnbA, fnbB, sdrC were detected but not cna. The isolates were negative for enterotoxin genes and tst, as well as for eta, and etb; agr-type was III.

Indexed as

Sequence Homology, Amino AcidAnimalsBacterial ProteinsBacterial Typing TechniquesCattleDrug Resistance, MicrobialGene Expression Regulation, BacterialGenes, BacterialGermanyHumansMethicillin-Resistant Staphylococcus aureusOligonucleotide Array Sequence AnalysisPenicillin-Binding ProteinsPolymerase Chain ReactionVirulenceBacterial ProteinsmecA protein, Staphylococcus aureusPenicillin-Binding Proteins

Identifiers

PMID21931689
PMCPMC3169590

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.