ArticleGenetics and molecular biology2011
Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population.
Article in Genetics and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Association between vitamin D metabolism gene polymorphisms and schizophrenia.Biomedical reports · 2024Article
- Vitamin D status and VDR gene polymorphisms in patients with growth hormone deficiency: A case control Tunisian study.Heliyon · 2024Article
- Vitamin D and musculoskeletal health: outstanding aspects to be considered in the light of current evidence.Endocrine connections · 2022Review
- Relationship of vitamin D receptor gene polymorphisms inClinical and experimental gastroenterology · 2018Article
- Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China.Clinical interventions in aging · 2017Article
- Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males.Public health nutrition · 2015Article
- Influence of ethnicity on the distribution of genetic polymorphisms associated with risk of chronic liver disease in South American populations.BMC genetics · 2015Article
- Vitamin D receptor variability and physical activity are jointly associated with low handgrip strength and osteoporosis in community-dwelling elderly people in Taiwan: the Taichung Community Health Study for Elders (TCHS-E).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Interethnic admixture and the evolution of Latin American populations.Genetics and molecular biology · 2014Review
- A systematic scoping review of the genetic ancestry of the Brazilian population.Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vitamin D receptor (VDR) is an essential protein related to bone metabolism. Some VDR alleles are differentially distributed among ethnic populations and display variable patterns of linkage disequilibrium (LD). In this study, 200 unrelated Brazilians were genotyped using 21 VDR single nucleotide polymorphisms (SNPs) and 28 ancestry informative markers. The patterns of LD and haplotype distribution were compared among Brazilian and the HapMap populations of African (YRI), European (CEU) and Asian (JPT+CHB) origins. Conditional regression and haplotype-specific analysis were performed using estimates of individual genetic ancestry in Brazilians as a quantitative trait. Similar patterns of LD were observed in the 5' and 3' gene regions. However, the frequency distribution of haplotype blocks varied among populations. Conditional regression analysis identified haplotypes associated with European and Amerindian ancestry, but not with the proportion of African ancestry. Individual ancestry estimates were associated with VDR haplotypes. These findings reinforce the need to correct for population stratification when performing genetic association studies in admixed populations.
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