ArticleInternational journal of nanomedicine2011
Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles.
Article in International journal of nanomedicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- FeCell adhesion & migration · 2024Article
- Surface Engineering of Nanomaterials with Polymers, Biomolecules, and Small Ligands for Nanomedicine.Materials (Basel, Switzerland) · 2022Review
- Nanomedicine to Overcome Multidrug Resistance Mechanisms in Colon and Pancreatic Cancer: Recent Progress.Cancers · 2021Review
- Tailor-Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2020Review
- Gambogic Acid as a Candidate for Cancer Therapy: A Review.International journal of nanomedicine · 2020Review
- Apoptotic Mechanism of Human Leukemia K562/A02 Cells Induced by Magnetic Ferroferric Oxide Nanoparticles Loaded with Wogonin.Chinese medical journal · 2016Article
- Molecular targets of gambogic acid in cancer: recent trends and advancements.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Emerging Therapeutic Potential of Nanoparticles in Pancreatic Cancer: A Systematic Review of Clinical Trials.Biomedicines · 2016Review
- Article
- Effective elimination of liver cancer stem-like cells by CD90 antibody targeted thermosensitive magnetoliposomes.Oncotarget · 2016Article
- Onivyde for the therapy of multiple solid tumors.OncoTargets and therapy · 2016Review
- Recent research on bioactive xanthones from natural medicine: Garcinia hanburyi.AAPS PharmSciTech · 2015Review
- Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways.World journal of gastroenterology · 2015Article
- Article
- Single-walled carbon nanotube and graphene nanodelivery of gambogic acid increases its cytotoxicity in breast and pancreatic cancer cells.Journal of applied toxicology : JAT · 2014Article
- Nanoconjugation: A Materials Approach to Enhance Epidermal Growth Factor Induced Apoptosis.Biomaterials science · 2014Article
- Preclinical evaluation of recombinant human IFNα2b-containing magnetoliposomes for treating hepatocellular carcinoma.International journal of nanomedicine · 2014Article
- Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death.International journal of nanomedicine · 2013Article
- Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells.International journal of nanomedicine · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGambogic acid (GA), a potent anticancer agent, is limited in clinical administration due to its poor water solubility. The aim of this study was to explore a drug delivery system based on magnetic Fe(3)O(4) nanoparticles (MNP-Fe(3)O(4)) conjugated with GA to increase water solubility of the drug and enhance its chemotherapeutic efficiency for pancreatic cancer.
methodsGA was conjugated with the MNP-Fe(3)O(4) colloidal suspension by mechanical absorption polymerization to construct GA-loaded MNP-Fe(3)O(4), which acted as a drug delivery system.
resultsCombination therapy with GA and MNP-Fe(3)O(4) induced remarkable improvement in anticancer activity, which was demonstrated by optical microscopic observations, MTT assay, and nuclear DAPI staining. Furthermore, the possible signaling pathway was explored by Western blot. In Capan-1 pancreatic cancer cells, our observations demonstrated that this strategy could enhance potential anticancer efficiency by inducing apoptosis. The mechanisms of the synergistic effect may be due to reducing protein expression of Bcl-2 and enhancing that of Bax, caspase 9, and caspase 3.
conclusionThese findings demonstrate that a combination of GA and MNPs-Fe(3)O(4) represents a promising approach to the treatment of pancreatic cancer.
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