Evidence map›Paper›PMID 21931480›Full record

ArticleInternational journal of nanomedicine2011

Silver nanoparticles embedded in zeolite membranes: release of silver ions and mechanism of antibacterial action.

Amber Nagy, Alistair Harrison, Supriya Sabbani, Robert S Munson, Prabir K Dutta, W James Waldman

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 284 citations in OpenAlex.

  1. Trial
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  4. Article
  5. Article
  6. Article
  7. Review
  8. Formulation of silymarin surface modified vesicles: In vitro characterization to cell viability assessment.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. PMMA/ABS/CoClMolecules (Basel, Switzerland) · 2022
    Article
  16. Article
  17. Rapid Synthesis of Metal Nanoparticles Using Low-Temperature, Low-Pressure Argon Plasma Chemistry and Self-Assembly.Green chemistry : an international journal and green chemistry resource : GC · 2022
    Article
  18. Article
  19. Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Amber NagyDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Alistair Harrison
Supriya Sabbani
Robert S Munson
Prabir K Dutta
W James Waldman
The Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe focus of this study is on the antibacterial properties of silver nanoparticles embedded within a zeolite membrane (AgNP-ZM). METHODS AND

resultsThese membranes were effective in killing Escherichia coli and were bacteriostatic against methicillin-resistant Staphylococcus aureus. E. coli suspended in Luria Bertani (LB) broth and isolated from physical contact with the membrane were also killed. Elemental analysis indicated slow release of Ag(+) from the AgNP-ZM into the LB broth. The E. coli killing efficiency of AgNP-ZM was found to decrease with repeated use, and this was correlated with decreased release of silver ions with each use of the support. Gene expression microarrays revealed upregulation of several antioxidant genes as well as genes coding for metal transport, metal reduction, and ATPase pumps in response to silver ions released from AgNP-ZM. Gene expression of iron transporters was reduced, and increased expression of ferrochelatase was observed. In addition, upregulation of multiple antibiotic resistance genes was demonstrated. The expression levels of multicopper oxidase, glutaredoxin, and thioredoxin decreased with each support use, reflecting the lower amounts of Ag(+) released from the membrane. The antibacterial mechanism of AgNP-ZM is proposed to be related to the exhaustion of antioxidant capacity.

conclusionThese results indicate that AgNP-ZM provide a novel matrix for gradual release of Ag(+).

Indexed as

Metal NanoparticlesZeolitesAnti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliGene ExpressionMaterials TestingMethicillin-Resistant Staphylococcus aureusMicroscopy, Electron, ScanningNanomedicineOligonucleotide Array Sequence AnalysisOxidative StressPowder DiffractionReverse Transcriptase InhibitorsSilverAnti-Bacterial AgentsReverse Transcriptase InhibitorsSilverZeolitesantibacterial agentoxidative stresssilver nanoparticleszeolite

Identifiers

PMID21931480
PMCPMC3173047
OpenAlexW2168600298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.