ArticleCell research2011
Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates.
Article in Cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 38 citations in OpenAlex.
- Toll-like receptor 4 pathway evolutionary trajectory and functional emergence.Frontiers in immunology · 2024Article
- A genome-wide search of Toll/Interleukin-1 receptor (TIR) domain-containing adapter molecule (TICAM) and their evolutionary divergence from other TIR domain containing proteins.Biology direct · 2022Article
- The role of RHIM in necroptosis.Biochemical Society transactions · 2022Article
- In search of the Aplysia immunome: an in silico study.BMC genomics · 2022Article
- Hepatic cecum: a key integrator of immunity in amphioxus.Marine life science & technology · 2021Review
- Article
- Bacterial Engulfment Mechanism Is Strongly Conserved in Evolution Between Earthworm and Human Immune Cells.Frontiers in immunology · 2021Article
- Innate immunity in the simplest animals - placozoans.BMC genomics · 2019Article
- Editorial: Ligands, Adaptors and Pathways of TLRs in Non-mammals.Frontiers in immunology · 2019Article
- Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals.Frontiers in immunology · 2018Review
- Hm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leech.Scientific reports · 2015Article
- MiR-27a ameliorates inflammatory damage to the blood-spinal cord barrier after spinal cord ischemia: reperfusion injury in rats by downregulating TICAM-2 of the TLR4 signaling pathway.Journal of neuroinflammation · 2015Article
- Establishing primary cell cultures from Branchiostoma belcheri Japanese.In vitro cellular & developmental biology. Animal · 2013Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MyD88-independent pathway, one of the two crucial TLR signaling routes, is thought to be a vertebrate innovation. However, a novel Toll/interleukin-1 receptor (TIR) adaptor, designated bbtTICAM, which was identified in the basal chordate amphioxus, links this pathway to invertebrates. The protein architecture of bbtTICAM is similar to that of vertebrate TICAM1 (TIR-containing adaptor molecule-1, also known as TRIF), while phylogenetic analysis based on the TIR domain indicated that bbtTICAM is the oldest ortholog of vertebrate TICAM1 and TICAM2 (TIR-containing adaptor molecule-2, also known as TRAM). Similar to human TICAM1, bbtTICAM activates NF-κB in a MyD88-independent manner by interacting with receptor interacting protein (RIP) via its RHIM motif. Such activation requires bbtTICAM to form homodimers in endosomes, and it may be negatively regulated by amphioxus SARM (sterile α and armadillo motif-containing protein) and TRAF2. However, bbtTICAM did not induce the production of type I interferon. Thus, our study not only presents the ancestral features of vertebrate TICAM1 and TICAM2, but also reveals the evolutionary origin of the MyD88-independent pathway from basal chordates, which will aid in understanding the development of the vertebrate TLR network.
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