ArticleBiomedical materials (Bristol, England)2011
Improved cellular infiltration into nanofibrous electrospun cross-linked gelatin scaffolds templated with micrometer-sized polyethylene glycol fibers.
Article in Biomedical materials (Bristol, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- In Vivo Cell Migration and Growth Within Electrospun Porous Nanofibrous Scaffolds with Different Pore Sizes in a Mouse Pouch Model.Journal of functional biomaterials · 2025Article
- Nanomedicine-Based Ophthalmic Drug Delivery Systems for the Treatment of Ocular Diseases.International journal of nanomedicine · 2025Review
- The Influence of Textile Structure Characteristics on the Performance of Artificial Blood Vessels.Polymers · 2023Review
- Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective.Nanotheranostics · 2023Review
- Review
- Cross-Linking Optimization for Electrospun Gelatin: Challenge of Preserving Fiber Topography.Polymers · 2020Article
- Electrospun Polymers in Cartilage Engineering-State of Play.Frontiers in bioengineering and biotechnology · 2020Review
- Cross-Linking Strategies for Electrospun Gelatin Scaffolds.Materials (Basel, Switzerland) · 2019Review
- Regenerative Engineering of the Rotator Cuff of the Shoulder.ACS biomaterials science & engineering · 2018Article
- Article
- Growth behavior of endothelial cells according to electrospun poly(D,L-lactic-co-glycolic acid) fiber diameter as a tissue engineering scaffold.Tissue engineering and regenerative medicine · 2016Article
- Synthetic vs natural scaffolds for human limbal stem cells.Croatian medical journal · 2015Article
- Osseointegrative properties of electrospun hydroxyapatite-containing nanofibrous chitosan scaffolds.Tissue engineering. Part A · 2015Article
- Improved cell infiltration of highly porous nanofibrous scaffolds formed by combined fiber-fiber charge repulsions and ultra-sonication.Journal of materials chemistry. B · 2014Article
- Electrospun polycaprolactone scaffolds with tailored porosity using two approaches for enhanced cellular infiltration.Journal of materials science. Materials in medicine · 2013Article
- Bioinspired nanofibers support chondrogenesis for articular cartilage repair.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Improved cellular infiltration in electrospun fiber via engineered porosity.Tissue engineering · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Gelatin-based nanofibrous scaffolds with a mean fiber diameter of 300 nm were prepared with and without micrometer-sized polyethylene glycol (PEG) fibers that served as sacrificial templates. Upon fabrication of the scaffolds via electrospinning, the gelatin fibers were crosslinked with glutaraldehyde, and the PEG templates were removed using tert-butanol to yield nanofibrous scaffolds with pore diameters ranging from 10 to 100 µm, as estimated with mercury intrusion porosimetry. Non-templated gelatin-based nanofibrous matrices had an average pore size of 1 µm. Fibroblasts were seeded onto both types of the gelatin-based nanofibrous surfaces and cultured for 14 days. For comparative purposes, chitosan-based and polyurethane-based macroporous scaffolds with pore sizes of 100 and 170 µm, respectively, were also included. The number of cells as a function of the depth into the scaffold was judged and quantitatively assessed using nuclei staining. Cell penetration up to a depth of 250 and 90 µm was noted in gelatin scaffolds prepared with sacrificial templates and gelatin-only nanofibrous scaffolds. Noticeably, scaffold preparation protocol presented here allowed the structural integrity to be maintained even with high template content (95%) and can easily be extended toward other classes of electrospun polymer matrices for tissue engineering.
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