ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2011
Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury.PloS one · 2022Article
- Article
- A misprocessed form of Apolipoprotein A-I is specifically associated with recurrent Focal Segmental Glomerulosclerosis.Scientific reports · 2020Article
- The Role and Function of HDL in Patients with Chronic Kidney Disease and the Risk of Cardiovascular Disease.International journal of molecular sciences · 2020Review
- Mechanisms of Injury in APOL1-associated Kidney Disease.Transplantation · 2019Review
- APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice.PloS one · 2019Article
- Kidney function is associated with an altered protein composition of high-density lipoprotein.Kidney international · 2017Article
- APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Article
- APOL1 Variants: From Parasites to Kidney Function to Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans.BMC genetics · 2015Article
- APOL1 Kidney Disease Risk Variants: An Evolving Landscape.Seminars in nephrology · 2015Review
- Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines.Journal of the American Society of Nephrology : JASN · 2015Article
- Histopathologic findings associated with APOL1 risk variants in chronic kidney disease.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates.Epigenetics · 2015Article
- The molecular arms race between African trypanosomes and humans.Nature reviews. Microbiology · 2014Review
- The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease.Clinical and experimental nephrology · 2014Review
- The kidney and lipids: preface.Clinical and experimental nephrology · 2014Article
- Plasma apolipoprotein L1 levels do not correlate with CKD.Journal of the American Society of Nephrology : JASN · 2014Article
- JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy.Kidney international · 2013Article
- APOL1 and nephropathy progression in populations of African ancestry.Seminars in nephrology · 2013Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCoding variants in the apolipoprotein L1 gene (APOL1) are strongly associated with non-diabetic nephropathy in African Americans. ApoL1 proteins associate with high-density lipoprotein (HDL) particles in the circulation. Plasma HDL particle subclass concentrations were compared in 73 African Americans based on APOL1 genotypes to detect differences potentially contributing to renal disease.
methodsHDL subclass concentrations were measured using nuclear magnetic resonance spectroscopy in African American first-degree relatives of patients with non-diabetic end-stage renal disease. Participants had estimated glomerular filtration rates (GFRs) > 80 mL/min and lacked albuminuria. Additive effects of the number of APOL1 risk variants on natural logarithm-transformed HDL subclass concentrations were computed.
resultsParticipants were 58.9% female with mean ± SD age 47.2 ± 13.3 years and GFR 92.4 ± 18.8 mL/min. The numbers with 2, 1 and 0 APOL1 nephropathy risk variants, respectively, were 36, 17 and 20. Mean ± SD medium-sized HDL concentrations were significantly lower for each additional APOL1 risk variant (2 versus 1 versus 0 risk variants: 9.0 ± 5.6 versus 10.1 ± 5.5 versus 13.1 ± 8.2 μmol/L, respectively; P = 0.0222 unadjusted; P = 0.0162 triglyceride- and ancestry adjusted).
conclusionsLower medium-sized HDL subclass concentrations are present in African Americans based on increasing numbers of APOL1 nephropathy risk variants. Potential mechanistic roles of altered medium HDL concentrations on APOL1-associated renal microvascular diseases should be evaluated.
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