Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2011
Costs of home versus inpatient treatment for fever and neutropenia: analysis of a multicenter randomized trial.
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 7 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Virtual healthcare compared to hospital care for acute and post-acute illness in adults: A systematic review and meta-analysis of randomized controlled trials.British journal of clinical pharmacology · 2026Pooled it
- Inpatient-level care at home delivered by virtual wards and hospital at home: a systematic review and meta-analysis of complex interventions and their components.BMC medicine · 2024Pooled it
- Admission avoidance hospital at home.The Cochrane database of systematic reviews · 2024Pooled it
- A concept analysis of transitional care for people with cancer.Nursing open · 2024Pooled it
- Ambulatory management of low-risk febrile neutropenia in adult oncological patients. Systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Outpatient treatment for people with cancer who develop a low-risk febrile neutropaenic event.The Cochrane database of systematic reviews · 2019Pooled it
- Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients.The Cochrane database of systematic reviews · 2013Pooled it
- Comparison of in-patient costs for children treated on the AAML0531 clinical trial: A report from the Children's Oncology Group.Pediatric blood & cancer · 2015Trial
- Safety of early discharge for low-risk patients with febrile neutropenia: a multicenter randomized controlled trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2011Trial
- Quantifying cost savings from outpatient parenteral antimicrobial therapy programme: a systematic review and meta-analysis.JAC-antimicrobial resistance · 2025Review
- Economic implications of step-down outpatient management for fever and neutropenia episodes in pediatric cancer patients: a cost minimization analysis.BMC health services research · 2024Article
- Usefulness analysis of the 2018 ASCO/IDSA guideline for outpatient management of fever and neutropenia in adults treated for malignancy.Scientific reports · 2021Article
- Potential reduction of hospital stay length with outpatient management of low-risk febrile neutropenia in a regional cancer center.Cancer reports (Hoboken, N.J.) · 2021Article
- DNA Methylation Events as Markers for Diagnosis and Management of Acute Myeloid Leukemia and Myelodysplastic Syndrome.Disease markers · 2017Review
- Outpatient management without initial assessment for febrile patients undergoing adjuvant chemotherapy for breast cancer.Molecular and clinical oncology · 2016Article
- Transition journey from hospital to home in patients with cancer and their caregivers: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Admission avoidance hospital at home.The Cochrane database of systematic reviews · 2016Review
- ReCAP: Hospitalizations in Older Adults With Advanced Cancer: The Role of Chemotherapy.Journal of oncology practice · 2016Article
- Ertapenem usage in cancer patients with and without neutropenia: a report on 97 cases from a comprehensive cancer center.Infection · 2015Article
- The impact of chemotherapy dose intensity and supportive care on the risk of febrile neutropenia in patients with early stage breast cancer: a prospective cohort study.SpringerPlus · 2015Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeFor patients with cancer who have febrile neutropenia, relative costs of home versus hospital treatment, including unreimbursed costs borne by patients and families, are poorly characterized. We estimated costs from a randomized trial of patients with low-risk febrile neutropenia for whom outpatient care was feasible, comparing inpatient treatment with discharge to home care after inpatient observation.
methodsWe collected direct medical and self-reported indirect costs for 57 inpatient and 35 outpatient treatment episodes of patients enrolled in a randomized trial from 1996 through 2000. Charges from hospital bills were converted to costs using Medicare cost-to-charge ratios. Patients kept daily logs of out-of-pocket payments and time spent by informal caregivers providing care. Dollar amounts were standardized to June 2008.
resultsMean total charges for the hospital arm were 49% higher than for the home treatment arm ($16,341 v $10,977; P < .01). Mean estimated total costs for the hospital arm were 30% higher ($10,143 v $7,830; P < .01). Inspection of sparse available data suggests that payments made were similar by treatment arm. Inpatients and their caregivers spent more out of pocket than their outpatient counterparts (mean, $201 v $74; P < .01). Informal caregivers for both treatment arms reported similar time caring and lost from work.
conclusionHome intravenous antibiotic treatment was less costly than continued inpatient care for carefully selected patients with cancer having febrile neutropenia without significantly increased indirect costs or caregiver burden.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.