ArticleProceedings of the National Academy of Sciences of the United States of America2011
Extensive divergence of yeast stress responses through transitions between induced and constitutive activation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Natural trait variation across Saccharomycotina species.FEMS yeast research · 2024Review
- Facing lethal temperatures: Heat-shock response in desert and temperate ants.Ecology and evolution · 2023Article
- Condition-specific 3' mRNA isoform half-lives and stability elements in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Pheno-RNA, a method to associate genes with a specific phenotype, identifies genes linked to cellular transformation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Transcriptome Profile of Yeast Strain Used for Biological Wine Aging Revealed Dynamic Changes of Gene Expression in Course of Flor Development.Frontiers in microbiology · 2020Article
- Resolving noise-control conflict by gene duplication.PLoS biology · 2019Article
- A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees.eLife · 2019Article
- CpG island composition differences are a source of gene expression noise indicative of promoter responsiveness.Genome biology · 2018Article
- Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation.Nature communications · 2018Article
- How transcription circuits explore alternative architectures while maintaining overall circuit output.Genes & development · 2017Review
- Duplication of a promiscuous transcription factor drives the emergence of a new regulatory network.Nature communications · 2014Article
- Ribosome profiling reveals post-transcriptional buffering of divergent gene expression in yeast.Genome research · 2014Article
- Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats.PloS one · 2014Article
- Msn2 coordinates a stoichiometric gene expression program.Current biology : CB · 2013Article
- Promoters maintain their relative activity levels under different growth conditions.Molecular systems biology · 2013Article
- Article
- Arboretum: reconstruction and analysis of the evolutionary history of condition-specific transcriptional modules.Genome research · 2013Article
- Evolution of a membrane protein regulon in Saccharomyces.Molecular biology and evolution · 2012Article
- A genomic bias for genotype-environment interactions in C. elegans.Molecular systems biology · 2012Article
- Abundant gene-by-environment interactions in gene expression reaction norms to copper within Saccharomyces cerevisiae.Genome biology and evolution · 2012Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Closely related species show a high degree of differences in gene expression, but the functional significance of these differences remains unclear. Similarly, stress responses in yeast typically involve differential expression of numerous genes, and it is unclear how many of these are functionally significant. To address these issues, we compared the expression programs of four yeast species under different growth conditions, and found that the response of these species to stress has diverged extensively. On an individual gene basis, most transcriptional responses are not conserved in any pair of species, and there are very limited common responses among all four species. We present evidence that many evolutionary changes in stress responses are compensated either (i) by the response of related genes or (ii) by changes in the basal expression levels of the genes whose responses have diverged. Thus, stress-related genes are often induced upon stress in some species but maintain high levels even in the absence of stress at other species, indicating a transition between induced and constitutive activation. In addition, ~15% of the stress responses are specific to only one of the four species, with no evidence for compensating effects or stress-related annotations, and these may reflect fortuitous regulation that is unimportant for the stress response (i.e., biological noise). Frequent compensatory changes and biological noise may explain how diverged expression responses support similar physiological responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.