ArticleAntimicrobial agents and chemotherapy2011
Molecular characteristics of KPC-producing Enterobacteriaceae at the early stage of their dissemination in Poland, 2008-2009.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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48 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of colistin resistance of Klebsiella pneumoniae isolates in Iran: a systematic review and meta-analysis.Annals of clinical microbiology and antimicrobials · 2022Pooled it
- Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis.BMJ open · 2016Pooled it
- Review
- Changes in Antibiotic Resistance ofJournal of clinical medicine · 2023Article
- Evolution of Antibiotic Resistance inJournal of clinical medicine · 2023Article
- Epidemiological and Molecular Characteristics ofInfection and drug resistance · 2023Article
- Occurrence and Characteristics of Carbapenem-ResistantPathogens (Basel, Switzerland) · 2022Article
- Klebsiella oxytoca Complex: Update on Taxonomy, Antimicrobial Resistance, and Virulence.Clinical microbiology reviews · 2022Article
- Clonal Dissemination of KPC-2, VIM-1, OXA-48-ProducingPolish journal of microbiology · 2021Article
- Transmission Dynamics of Carbapenem-ResistantFrontiers in microbiology · 2021Article
- Discovery of small-molecule inhibitors of multidrug-resistance plasmid maintenance using a high-throughput screening approach.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Identification of a Carbapenemase-Producing Hypervirulent Klebsiella pneumoniae Isolate in the United States.Antimicrobial agents and chemotherapy · 2019Article
- Carbapenemase-producing bacteria in food-producing animals, wildlife and environment: A challenge for human health.Italian journal of food safety · 2019Article
- CG258 Klebsiella pneumoniae isolates without β-lactam resistance at the onset of the carbapenem-resistant Enterobacteriaceae epidemic in New York City.The Journal of antimicrobial chemotherapy · 2019Observational
- Article
- Transcriptional Landscape of aFrontiers in microbiology · 2018Article
- Whole genome sequence revealed the fine transmission map of carbapenem-resistantAntimicrobial resistance and infection control · 2018Article
- Carbapenem Resistance: A Review.Medical sciences (Basel, Switzerland) · 2017Review
- Article
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13 authors.
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Abstract
After the first report in May 2008, the National Reference Center for Susceptibility Testing confirmed 113 cases of infection or colonization by KPC-producing members of the family Enterobacteriaceae in Poland by the end of 2009. The vast majority of patients were found in 18 hospitals; three patients were diagnosed at outpatient clinics. Most of the institutions were in the Warsaw area, including three hospitals with the highest numbers of cases. When available, the data on previous hospitalizations often indicated that these hospitals were the probable acquisition sites; one patient arrived from New York. The group of 119 unique isolates consisted of Klebsiella pneumoniae (n = 114), followed by Klebsiella oxytoca (n = 3), and Escherichia coli (n = 2). The K. pneumoniae isolates were dominated by the clone sequence type 258 (ST258) (n = 111); others were ST11 and ST23. The ST258 group was heterogeneous, with 28 pulsed-field gel electrophoresis (PFGE) subtypes, ∼25 plasmid profiles, and nine β-lactamase patterns differing by KPC variants (KPC-2 mainly), and SHV-12, CTX-M-3, and TEM-1-like enzymes. Plasmids carrying bla(KPC) genes varied in size (~48 to 250 kb), structure, and conjugation potential. Transferable IncFII(K) plasmids of ~110 to 160 kb, probably pKpQIL or its derivatives, were observed in all K. pneumoniae clones and in K. oxytoca. Also prevalent were nontypeable pETKp50-like plasmids of ~50 kb, found in K. pneumoniae ST258 and E. coli isolates (ST93 and ST224). Two K. pneumoniae-E. coli pairs from single patients might represent the in vivo transfer of such plasmids. The striking diversity of KPC producers at the early stage of dissemination could result from several introductions of these bacteria into the country, their multidirectional evolution during clonal spread, and transfer of the plasmids.
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