ArticleAntimicrobial agents and chemotherapy2011
Fluoroquinolone efflux in Streptococcus suis is mediated by SatAB and not by SmrA.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Pan-genome analysis ofFrontiers in microbiology · 2024Article
- Role of Metabolic Adaptation ofPathogens (Basel, Switzerland) · 2023Review
- Assessment of microbiota in the gut and upper respiratory tract associated with SARS-CoV-2 infection.Microbiome · 2023Article
- Role of PatAB Transporter in Efflux of Levofloxacin inAntibiotics (Basel, Switzerland) · 2022Article
- How Streptococcus suis escapes antibiotic treatments.Veterinary research · 2022Review
- Role of the Two-Component System CiaRH in the Regulation of Efflux Pump SatAB and Its Correlation with Fluoroquinolone Susceptibility.Microbiology spectrum · 2022Article
- Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic PathogenMicroorganisms · 2021Review
- Serotypes, Virulence-Associated Factors, and Antimicrobial Resistance ofFrontiers in veterinary science · 2021Article
- Genome sequences of antibiotic-resistant Streptococcus suis strains isolated from human patients and diseased and asymptomatic pigs in Thailand.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Patterns of antimicrobial resistance in Streptococcus suis isolates from pigs with or without streptococcal disease in England between 2009 and 2014.Veterinary microbiology · 2017Article
- Highly Tigecycline-Resistant Klebsiella pneumoniae Sequence Type 11 (ST11) and ST147 Isolates from Companion Animals.Antimicrobial agents and chemotherapy · 2017Article
- PK-PD Analysis of Marbofloxacin againstFrontiers in pharmacology · 2017Article
- Upregulation of the PatAB Transporter Confers Fluoroquinolone Resistance toFrontiers in microbiology · 2017Article
- Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.Cold Spring Harbor perspectives in medicine · 2016Review
- The GAS PefCD exporter is a MDR system that confers resistance to heme and structurally diverse compounds.BMC microbiology · 2016Article
- Mechanisms of drug resistance: quinolone resistance.Annals of the New York Academy of Sciences · 2015Review
- SatR is a repressor of fluoroquinolone efflux pump SatAB.Antimicrobial agents and chemotherapy · 2013Article
- Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen.Frontiers in microbiology · 2011Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus suis is an emerging zoonotic pathogen. With the lack of an effective vaccine, antibiotics remain the main tool to fight infections caused by this pathogen. We have previously observed a reserpine-sensitive fluoroquinolone (FQ) efflux phenotype in this species. Here, SatAB and SmrA, two pumps belonging to the ATP binding cassette (ABC) and the major facilitator superfamily (MFS), respectively, have been analyzed in the fluoroquinolone-resistant clinical isolate BB1013. Genes encoding these pumps were overexpressed either constitutively or in the presence of ciprofloxacin in this strain. These genes could not be cloned in plasmids in Escherichia coli despite strong expression repression. Finally, site-directed insertion of smrA and satAB in the amy locus of the Bacillus subtilis chromosome using ligated PCR amplicons allowed for the functional expression and study of both pumps. Results showed that SatAB is a narrow-spectrum fluoroquinolone exporter (norfloxacin and ciprofloxacin), susceptible to reserpine, whereas SmrA was not involved in fluoroquinolone resistance. Chromosomal integration in Bacillus is a novel method for studying efflux pumps from Gram-positive bacteria, which enabled us to demonstrate the possible role of SatAB, and not SmrA, in fluoroquinolone efflux in S. suis.
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