ArticleCancer prevention research (Philadelphia, Pa.)2012
Dispersal evolution in neoplasms: the role of disregulated metabolism in the evolution of cell motility.
Article in Cancer prevention research (Philadelphia, Pa.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
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- Searching for Goldilocks: How Evolution and Ecology Can Help Uncover More Effective Patient-Specific Chemotherapies.Cancer research · 2020Review
- Metastasis and the evolution of dispersal.Proceedings. Biological sciences · 2019Article
- Evidence of conditioned behavior in amoebae.Nature communications · 2019Article
- Ecological feedback on diffusion dynamics.Royal Society open science · 2019Article
- Energy oversupply to tissues: a single mechanism possibly underlying multiple cancer risk factors.Evolution, medicine, and public health · 2019Article
- Cancer initiation and progression within the cancer microenvironment.Clinical & experimental metastasis · 2018Review
- Life History Trade-Offs in Tumors.Current pathobiology reports · 2018Review
- Resource competition promotes tumour expansion in experimentally evolved cancer.BMC evolutionary biology · 2017Article
- Classifying the evolutionary and ecological features of neoplasms.Nature reviews. Cancer · 2017Review
- Cancer: A disease at the crossroads of trade-offs.Evolutionary applications · 2017Article
- Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks.Cold Spring Harbor perspectives in medicine · 2017Review
- Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation.Molecular cancer · 2017Review
- Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces.Cancer research · 2016Article
- Principles of cooperation across systems: from human sharing to multicellularity and cancer.Evolutionary applications · 2016Article
- Learning about the Importance of Mutation Prevention from Curable Cancers and Benign Tumors.Journal of Cancer · 2016Review
- Cancer across the tree of life: cooperation and cheating in multicellularity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Can oncology recapitulate paleontology? Lessons from species extinctions.Nature reviews. Clinical oncology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Here, we apply the theoretical framework of dispersal evolution to understand the emergence of invasive and metastatic cells. We investigate whether the dysregulated metabolism characteristic of cancer cells may play a causal role in selection for cell motility, and thus to the tissue invasion and metastasis that define cancer. With an agent-based computational model, we show that cells with higher metabolism evolve to have higher rates of movement and that "neoplastic" cells with higher metabolism rates are able to persist in a population of "normal" cells with low metabolic rates, but only if increased metabolism is accompanied by increased motility. This is true even when the cost of motility is high. These findings suggest that higher rates of cell metabolism lead to selection for motile cells in premalignant neoplasms, which may preadapt cells for subsequent invasion and metastasis. This has important implications for understanding the progression of cancer from less invasive to more invasive cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.