Trial reportThe Journal of physiology2011
Arterial pressure oscillations are not associated with muscle sympathetic nerve activity in individuals exposed to central hypovolaemia.
Trial report in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Repeated whole-body cryostimulation promotes a blood pressure reduction at rest in healthy adult men.European journal of applied physiology · 2026Trial
- Set configuration influences cardiovascular responses to resistance exercise in postmenopausal females in a randomized crossover trial from the CARE project.Scientific reports · 2025Trial
- Influence of an acute fast on ambulatory blood pressure and autonomic cardiovascular control.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- The effect of water temperature on orthostatic tolerance: a randomised crossover trial.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Trial
- McDAPS: A multi-channel physiological signals display and analysis system for clinical researchers.SoftwareX · 2023Article
- The potential therapeutic benefits of low frequency haemodynamic oscillations.The Journal of physiology · 2022Article
- Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes.Frontiers in physiology · 2021Article
- Hemorrhage simulated by lower body negative pressure provokes an oxidative stress response in healthy young adults.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Regulation of regional cerebral blood flow during graded reflex-mediated sympathetic activation via lower body negative pressure.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Wavelet decomposition analysis is a clinically relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury.American journal of physiology. Heart and circulatory physiology · 2018Article
- Variability in integration of mechanisms associated with high tolerance to progressive reductions in central blood volume: the compensatory reserve.Physiological reports · 2016Article
- Simultaneous Characterization of Sympathetic and Cardiac Arms of the Baroreflex through Sequence Techniques during Incremental Head-Up Tilt.Frontiers in physiology · 2016Article
- Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: lessons from postural tachycardia syndrome and obesity.American journal of physiology. Heart and circulatory physiology · 2015Article
- Greater autonomic modulation during post-exercise hypotension following high-intensity interval exercise in endurance-trained men and women.European journal of applied physiology · 2015Article
- Simulations of gravitational stress on normovolemic and hypovolemic men and women.Aviation, space, and environmental medicine · 2014Article
- Validation of lower body negative pressure as an experimental model of hemorrhage.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Aortic distensibility is reduced during intense lower body negative pressure and is related to low frequency power of systolic blood pressure.European journal of applied physiology · 2013Article
- Extracting autonomic information from oscillations in MSNA.The Journal of physiology · 2012Article
- Sympathetic responses to central hypovolemia: new insights from microneurographic recordings.Frontiers in physiology · 2012Article
- Caveat utilitor: take measure of your marker.The Journal of physiology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spectral power of low frequency oscillations of systolic arterial pressure (SAP(LF)) has been used as a non-invasive surrogate of muscle sympathetic nerve activity (MSNA) in both experimental and clinical situations. For SAP(LF) to be used in this way, a relationship must exist between SAP(LF) and MSNA within individuals during sympathetic activation. Using progressive central hypovolaemia to induce sympathetic activation, we hypothesised that SAP(LF) would correlate with MSNA in all subjects. ECG, beat-by-beat arterial pressure and MSNA were recorded in humans (n = 20) during a progressive lower body negative pressure (LBNP) protocol designed to cause presyncope in all subjects. Arterial pressure oscillations were assessed in the low frequency (LF; 0.04-0.15 Hz) domain using a Fourier transform. For the entire group, SAP(LF), MSNA burst frequency, and total MSNA increased during LBNP. Values for coefficients of determination (r(2)) describing the linear associations of SAP(LF) with MSNA burst frequency and total MSNA were 0.73 and 0.84, but rose to 0.89 and 0.98 when curvilinear fits were used, indicating that the relationship is curvilinear rather than linear. Associations between SAP(LF) and MSNA within each individual subject, however, varied widely for both MSNA burst frequency and total MSNA, whether derived by linear (r(2) range, 1.7 × 10(-6) to 0.99) or polynomial (r(2) range, 0.09 to 1.0) regression analysis. Similar results were obtained when relationships between low frequency oscillations in diastolic arterial pressure and MSNA were evaluated. These results do not support the use of low frequency oscillations in arterial pressure as a non-invasive measure of sympathetic outflow for individual subjects during sympathetic activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.