ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2011
A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- The Emergence of Life in the Light of Evolution.ArXiv · 2026Article
- The selfish ribosome.PLoS biology · 2026Article
- The selfish ribosome.ArXiv · 2026Article
- Reflections on the Origin of Coded Protein Biosynthesis.Biomolecules · 2024Review
- How to build a protoribosome: structural insights from the first protoribosome constructs that have proven to be catalytically active.RNA (New York, N.Y.) · 2023Article
- A Short Tale of the Origin of Proteins and Ribosome Evolution.Microorganisms · 2022Review
- Origin of life: protoribosome forms peptide bonds and links RNA and protein dominated worlds.Nucleic acids research · 2022Article
- The Peptidyl Transferase Center: a Window to the Past.Microbiology and molecular biology reviews : MMBR · 2021Article
- Origin of the 16S Ribosomal Molecule from Ancestor tRNAs.Journal of molecular evolution · 2021Article
- The Ancient History of Peptidyl Transferase Center Formation as Told by Conservation and Information Analyses.Life (Basel, Switzerland) · 2020Article
- Piece by piece: Building a ribozyme.The Journal of biological chemistry · 2020Review
- Archaeal Ribosomal Proteins Possess Nuclear Localization Signal-Type Motifs: Implications for the Origin of the Cell Nucleus.Molecular biology and evolution · 2020Article
- Differences in the path to exit the ribosome across the three domains of life.Nucleic acids research · 2019Article
- Prebiotic Iron Originates the Peptidyl Transfer Origin.Molecular biology and evolution · 2019Article
- The evolutionary dynamics of metabolic protocells.PLoS computational biology · 2018Article
- The Central Symbiosis of Molecular Biology: Molecules in Mutualism.Journal of molecular evolution · 2017Review
- Peptidyl Transferase Center and the Emergence of the Translation System.Life (Basel, Switzerland) · 2017Article
- Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function.Nature chemistry · 2017Article
- The double life of the ribosome: When its protein folding activity supports prion propagation.Prion · 2017Review
- The fluctuating ribosome: thermal molecular dynamics characterized by neutron scattering.Scientific reports · 2016Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Based on the presumed capability of a prebiotic pocket-like entity to accommodate substrates whose stereochemistry enables the creation of chemical bonds, it is suggested that a universal symmetrical region identified within all contemporary ribosomes originated from an entity that we term the 'proto-ribosome'. This 'proto-ribosome' could have evolved from an earlier machine that was capable of performing essential tasks in the RNA world, called here the 'pre-proto-ribosome', which was adapted for producing proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.