ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2011
The chemical versatility of RNA.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Peptides En Route from Prebiotic to Biotic Catalysis.Accounts of chemical research · 2024Article
- Imaginary Ribozymes.ACS chemical biology · 2020Article
- Face-time with TAR: Portraits of an HIV-1 RNA with diverse modes of effector recognition relevant for drug discovery.The Journal of biological chemistry · 2019Review
- An intricate balance of hydrogen bonding, ion atmosphere and dynamics facilitates a seamless uracil to cytosine substitution in the U-turn of the neomycin-sensing riboswitch.Nucleic acids research · 2018Article
- Engineering the RNA-Nanobio Interface.Bioengineering (Basel, Switzerland) · 2017Review
- Molecular Mechanisms of Enzyme Activation by Monovalent Cations.The Journal of biological chemistry · 2016Review
- Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+).Chemical communications (Cambridge, England) · 2016Article
- The emergence of DNA in the RNA world: an in silico simulation study of genetic takeover.BMC evolutionary biology · 2015Article
- Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme.Nature communications · 2015Article
- The ribosome challenge to the RNA world.Journal of molecular evolution · 2015Review
- Role of tautomerism in RNA biochemistry.RNA (New York, N.Y.) · 2015Review
- Looked at life from both sides now.Life (Basel, Switzerland) · 2014Review
- Purine biosynthetic intermediate-containing ribose-phosphate polymers as evolutionary precursors to RNA.Journal of molecular evolution · 2014Article
- Alternative substrate kinetics of Escherichia coli ribonuclease P: determination of relative rate constants by internal competition.The Journal of biological chemistry · 2013Article
- The RNA world hypothesis: the worst theory of the early evolution of life (except for all the others)(a).Biology direct · 2012Article
- The chemical origins of life and its early evolution: an introduction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ability of RNA to both store genetic information and catalyse chemical reactions has led to the hypothesis that it predates DNA and proteins. While there is no doubt that RNA is capable of storing the genetic information of a primitive organism, only two classes of reactions-phosphoryl transfer and peptide bond formation-have been observed to be catalysed by RNA in nature. However, these naturally occurring ribozymes use a wide range of catalytic strategies that could be applied to other reactions. Furthermore, RNA can bind several cofactors that are used by protein enzymes to facilitate a wide variety of chemical processes. Despite its limited functional groups, these observations indicate RNA is a versatile molecule that could, in principle, catalyse the myriad reactions necessary to sustain life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.