ArticleJournal of psychiatric research2012
The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients.
Article in Journal of psychiatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Trans-ancestry meta-analysis of genome wide association studies of inhibitory control.Molecular psychiatry · 2023Pooled it
- Association of the HTR2A gene with alcohol and heroin abuse.Human genetics · 2014Pooled it
- Decoding the serotonin-alcohol crosstalk: the role of central serotonergic dysregulation in alcohol use disorder.Pharmacological reports : PR · 2026Review
- Similarities and Differences in Genetics.Advances in experimental medicine and biology · 2025Review
- Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes.Biomolecules · 2024Article
- Article
- Tabernanthalog Reduces Motivation for Heroin and Alcohol in a Polydrug Use Model.Psychedelic medicine (New Rochelle, N.Y.) · 2023Article
- Protein-protein interactions underlying the behavioral and psychological symptoms of dementia (BPSD) and Alzheimer's disease.PloS one · 2020Article
- Connection between polymorphisms inJournal of genetics · 2019Article
- Association of rs4680Frontiers in psychiatry · 2019Article
- The association between impulsivity, emotion regulation, and symptoms of alcohol use disorder.Journal of substance abuse treatment · 2018Article
- Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation.Psychiatry research · 2018Article
- Hierarchical investigation of genetic influences on response inhibition in healthy young adults.Experimental and clinical psychopharmacology · 2017Article
- Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models.Pharmacogenomics · 2017Review
- Fractionating impulsivity: neuropsychiatric implications.Nature reviews. Neuroscience · 2017Review
- Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits.PloS one · 2015Article
- An insight into the understanding of 5-HTR2A variants leading to schizophrenia.The Indian journal of medical research · 2014Article
- Predictors of alcohol and drug dependence.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2014Article
- Multidimensional examination of impulsivity in relation to disordered gambling.Experimental and clinical psychopharmacology · 2014Article
- Individual differences in positivity offset and negativity bias: Gender-specific associations with two serotonin receptor genes.Personality and individual differences · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
High levels of impulsivity can increase the vulnerability for development of alcohol dependence. Moreover, impulsivity is considered to be a predictor of poor treatment outcomes. Few studies, however, have directly examined the genetics of impulsivity in alcohol-dependent patients. We analyzed the relationships between a well-recognized genetic marker of serotonin activity and levels of impulsivity as measured by both the Barratt Impulsiveness Scale (BIS-11) and the stop-signal task among 304 alcohol-dependent patients. The stop-signal task was used as an independent, objective method of estimating the level of behavioral impulsivity, and the BIS-11 as a self-report measure of global impulsivity. Blood was collected and analyzed for the T102C (rs6313) polymorphism in the serotonin type 2A receptor gene (HTR2A). Our results indicate a significant association between high levels of behavioral impulsivity and the C/C genotype of rs6313 in alcohol-dependent patients. The CC genotype has been previously found to be associated with a reduction in 5HT2A receptors in the central nervous system. These results support the hypothesis that genetic factors are important determinants of behavioral impulsivity in alcohol-dependent patients, and that the serotonin system plays an important role in establishing its level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.