ArticleAtherosclerosis2011
Differential effects of daily-moderate versus weekend-binge alcohol consumption on atherosclerotic plaque development in mice.
Article in Atherosclerosis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A systematic review of self-report measures used in epidemiological studies to assess alcohol consumption among older adults.PloS one · 2021Pooled it
- Effect of wine on carotid atherosclerosis in type 2 diabetes: a 2-year randomized controlled trial.European journal of clinical nutrition · 2018Trial
- A biphasic effect of alcohol on endothelial plasticity through regulation of endothelial-to-mesenchymal transition.American journal of physiology. Heart and circulatory physiology · 2026Article
- Prevalence of alcohol use disorder and its association with disease severity in symptomatic peripheral arterial disease.Scientific reports · 2026Observational
- New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting.Alcohol (Fayetteville, N.Y.) · 2025Article
- Endothelial Homeostasis Under the Influence of Alcohol-Relevance to Atherosclerotic Cardiovascular Disease.Nutrients · 2025Review
- Alcohol and vascular endothelial function: Biphasic effect highlights the importance of dose.Alcohol, clinical & experimental research · 2023Article
- Caveolin-1 inhibition mediates the opposing effects of alcohol on γ-secretase activity in arterial endothelial and smooth muscle cells.Physiological reports · 2023Article
- Extracellular-superoxide dismutase DNA methylation promotes oxidative stress in homocysteine-induced atherosclerosis.Acta biochimica et biophysica Sinica · 2022Article
- Exosomal Composition, Biogenesis and Profiling Using Point-of-Care Diagnostics-Implications for Cardiovascular Disease.Frontiers in cell and developmental biology · 2022Review
- Moderate dose alcohol protects against serum amyloid protein A1-induced endothelial dysfunction via both notch-dependent and notch-independent pathways.Alcoholism, clinical and experimental research · 2021Article
- Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and their Myogenic Progeny in Vascular Lesions.Stem cell reviews and reports · 2021Article
- The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions.NPJ Regenerative medicine · 2021Article
- Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study.European journal of nutrition · 2021Article
- Alcohol Binge Drinking Selectively Stimulates Protein S-Glutathionylation in Aorta and Liver ofFrontiers in cardiovascular medicine · 2021Article
- Moderate Alcohol Consumption Targets S100βAlcoholism, clinical and experimental research · 2020Article
- Genetic instrumental variable analysis: time to call mendelian randomization what it is. The example of alcohol and cardiovascular disease.European journal of epidemiology · 2020Review
- Wine and Health-New Evidence.European journal of clinical nutrition · 2019Review
- Association of High-Intensity Binge Drinking With Lipid and Liver Function Enzyme Levels.JAMA network open · 2019Observational
- Alcohol Pattern Consumption Differently Affects the Efficiency of Macrophage Reverse Cholesterol Transport in Vivo.Nutrients · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe examined the effect of daily-moderate (2 drinks/day, 7 days/week) and weekend-binge (7 drinks/day, 2 days/week) patterns of alcohol consumption on plasma lipid levels and physiological parameters of atherosclerotic plaque development.
methodsApoE k/o mouse were fed (1) 'daily-moderate' (blood alcohol content: 0.07%) or (2) 'weekend-binge' (blood alcohol content: 0.23%), or (3) an isocaloric cornstarch mix. Then, to induce atherosclerotic plaque formation, all groups underwent partial carotid artery ligation, started on an atherogenic diet and continued on the alcohol feeding regimen. After 2 weeks plasma lipid levels and atherosclerotic plaque formation were assessed.
resultsWhile there was an increase in HDL-C levels in both binge and moderate groups, LDL-C levels were significantly decreased in the daily-moderate drinking mice and significantly elevated in the weekend-binge drinking mice. In the daily-moderate alcohol group there was a decrease in atherosclerotic plaque volume, concomitant with an increase in lumen volume and decreased macrophage accumulation, when compared to no alcohol mice. In contrast, after 4 weeks of weekend-binge alcohol there was an increase in plaque volume, concomitant with a decrease in lumen volume and increased deposition of macrophages.
conclusionThese findings demonstrate for the first time a differential effect of daily-moderate vs. weekend-binge alcohol consumption on atherosclerotic plaque development and highlight the importance of patterns of alcohol consumption, as opposed to total amount consumed, in relation to the cardiovascular effects of alcohol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.