ArticleAnnals of tropical medicine and parasitology2011
Cases of cryptosporidiosis co-infections in AIDS patients: a correlation between clinical presentation and GP60 subgenotype lineages from aged formalin-fixed stool samples.
Article in Annals of tropical medicine and parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Anthroponotic transmission of Cryptosporidium parvum predominates in countries with poorer sanitation: a systematic review and meta-analysis.Parasites & vectors · 2019Pooled it
- Gastritis and AIDS-related cholangiopathy as an unusual presentation of HIV infection.Gastroenterology report · 2026Article
- Assessment ofInfectious disease reports · 2025Article
- Gut Microbial Signatures Associated with Cryptosporidiosis: A Case Series.Microorganisms · 2025Article
- Case Report: The impact of severe cryptosporidiosis on the gut microbiota of a pediatric patient with CD40L immunodeficiency.Frontiers in cellular and infection microbiology · 2023Article
- First Molecular Characterization ofPathogens (Basel, Switzerland) · 2021Article
- Prevalence and distribution pattern of Cryptosporidium spp. among pre-weaned diarrheic calves in the Republic of Korea.PloS one · 2021Article
- Cryptosporidium infections in sheep farms from Italy.Parasitology research · 2020Article
- Epidemiology of Cryptosporidiosis in France from 2017 to 2019.Microorganisms · 2020Article
- First detection of Cryptosporidium DNA in blood and cerebrospinal fluid of HIV-infected patients.Parasitology research · 2018Article
- Multilocus typing of Cryptosporidium spp. in young calves with diarrhea in Korea.Veterinary parasitology · 2016Article
- Burden of disease from cryptosporidiosis.Current opinion in infectious diseases · 2012Review
- Evidence of host-associated populations of Cryptosporidium parvum in Italy.Applied and environmental microbiology · 2012Article
- Molecular epidemiologic tools for waterborne pathogensFood and waterborne parasitologyReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nine cases of cryptosporidiosis co-infections in AIDS patients were clinically categorised into severe (patients 1, 3, 8 and 9), moderate (patients 4 and 5) and mild (patients 2, 6 and 7). Formalin-fixed faecal specimens from these patients were treated to obtain high quality DNA competent for amplification and sequencing of the 60-kDa glycoprotein (GP60) gene. Sequence analysis revealed that one patient was infected with Cryptosporidium hominis whereas the remaining eight patients were infected with C. parvum. Interestingly, the patients showing severe cryptosporidiosis harboured two subtypes within the C. parvum allelic family IIc (IIcA5G3 and IIcA5G3R2), whereas patients with moderate or mild infections showed various subtypes of the C. parvum allelic family IIa (IIaA14G2R1, IIaA15G2R1, IIaA17G3R1 and IIaA18G3R1). DNA extraction and genotyping of Cryptosporidium spp. is a challenging task on formalin-fixed stool samples, whose diagnostic outcome is age-dependent. The method herein reported represents a step forward routine diagnosis and improves epidemiology of HIV-related clinical cases. Due to the need to elucidate genetic richness of Cryptosporidium human isolates, this approach represents a useful tool to correlate individual differences in symptoms to subgenotyping lineages.
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