ArticleBMC medicine2011
A functional tandem-repeats polymorphism in the downstream of TERT is associated with the risk of nasopharyngeal carcinoma in Chinese population.
Article in BMC medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Modified triple Kessler with least risk of elongation among Achilles tendon repair techniques: a systematic review and network meta-analysis of human cadaveric studies.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Pooled it
- MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.PloS one · 2013Pooled it
- Analysis of MNS16A VNTR polymorphic sequence variations of theCurrent urology · 2021Article
- The MNS16A VNTR polymorphism of the TERT gene in bladder cancer.Turkish journal of urology · 2020Article
- Variability within the humanOncoTargets and therapy · 2019Article
- MNS16A tandem repeat minisatellite of human telomerase gene: functional studies in colorectal, lung and prostate cancer.Oncotarget · 2017Article
- Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis.BMC cancer · 2015Article
- Association of miR-146a gene polymorphism with risk of nasopharyngeal carcinoma in the central-southern Chinese population.Journal of human genetics · 2014Article
- Association study between miR-149 gene polymorphism and nasopharyngeal carcinoma.Biomedical reports · 2013Article
- HTERT MNS16A polymorphism in breast cancer: a case-control study.Molecular biology reports · 2012Article
- Genetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000-2011: Rosetta Stone for NPC: genetics, viral infection, and other environmental factors.Seminars in cancer biology · 2012Review
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreases in human telomerase reverse transcriptase (TERT) expression and telomerase activity are frequently seen in nasopharyngeal carcinoma (NPC). Recently, a variable tandem-repeats polymorphism, MNS16A, located in the downstream region of the TERT gene, was identified and reported to have an effect on TERT expression and telomerase activity. We examined whether the functional MNS16A was related to the risk of occurrence or progression of NPC in the Chinese population.
methodsWe genotyped the MNS16A polymorphism in a case-control study of 855 patients with NPC and 1036 cancer-free controls using PCR, and determined genotype by classifying the DNA band of 243 or 272 base pairs (bp) as the short (S) allele and 302 or 333 bp as the long (L) allele. The genetic associations with the risk of NPC were analyzed by logistic regression.
resultsThe MNS16A genotype was not associated with the progression of NPC. However, individuals carrying the S alleles (SL + SS genotype) had a significantly reduced risk of NPC occurrence compared with those carrying the LL genotype (odds ratio (OR) = 0. 71, 95% confidence interval (CI) = 0. 52 to 0. 96, P = 0. 025). Using a immunohistochemical assay on the NPC tissues, the SL genotype carriers were found to have lower TERT expression than the LL genotype carriers (P = 0. 035).
conclusionsOur study indicates that the TERT MNS16A polymorphism may contribute to the risk of NPC onset in Chinese population.
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