ArticleBMC molecular biology2011
A small basic protein from the brz-brb operon is involved in regulation of bop transcription in Halobacterium salinarum.
Article in BMC molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- A Two-Component Regulatory System Mediates Quorum Sensing-Dependent Morphology and Motility Transitions in the ArchaeonbioRxiv : the preprint server for biology · 2025Article
- Expanded Dataset Reveals the Emergence and Evolution of DNA Gyrase in Archaea.Molecular biology and evolution · 2022Article
- The hyperthermophilic archaeon Thermococcus kodakarensis is resistant to pervasive negative supercoiling activity of DNA gyrase.Nucleic acids research · 2021Article
- Insights into gene regulation of the halovirus His2 infecting Haloarcula hispanica.MicrobiologyOpen · 2020Article
- Deciphering Pathways for Carotenogenesis in Haloarchaea.Molecules (Basel, Switzerland) · 2020Article
- The Primary Antisense Transcriptome ofGenes · 2019Article
- In silico and experimental improvement of bacteriorhodopsin production in Halobacterium salinarum R1 by increasing DNA-binding affinity of Bat through Q661R/Q665R substitutions in HTH motif.Extremophiles : life under extreme conditions · 2019Article
- Complex Effects of Cytochrome P450 Monooxygenase on Purple Membrane and Bacterioruberin Production in an Extremely Halophilic Archaeon: Genetic, Phenotypic, and Transcriptomic Analyses.Frontiers in microbiology · 2018Article
- Transcriptome analysis of Haloquadratum walsbyi: vanity is but the surface.BMC genomics · 2017Article
- Genome-wide responses of the model archaeon Halobacterium sp. strain NRC-1 to oxygen limitation.Journal of bacteriology · 2012Article
- A workflow for genome-wide mapping of archaeal transcription factors with ChIP-seq.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe halophilic archaeon Halobacterium salinarum expresses bacteriorhodopsin, a retinal-protein that allows photosynthetic growth. Transcription of the bop (bacterioopsin) gene is controlled by two transcription factors, Bat and Brz that induce bop when cells are grown anaerobically and under light.
resultsA new gene was identified that is transcribed together with the brz gene that encodes a small basic protein designated as Brb (bacteriorhodopsin-regulating basic protein). The translation activity of the start codon of the brb gene was confirmed by BgaH reporter assays. In vivo site-directed mutagenesis of the brb gene showed that the Brb protein cooperates with Brz in the regulation of bop expression. Using a GFP reporter assay, it was demonstrated that Brb cooperates with both Brz and Bat proteins to activate bop transcription under phototrophic growth conditions.
conclusionsThe activation of the bop promoter was shown to be dependent not only on two major factors, Bat and Brz, but is also tuned by the small basic protein, Brb.
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