ArticleCritical care (London, England)2011
Preoperative regional cerebral oxygen saturation is a predictor of postoperative delirium in on-pump cardiac surgery patients: a prospective observational trial.
Article in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 77 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Intraoperative Cerebral Oxygen Desaturation on Post-Operative Delirium in Thoracic Surgical Patients: A Pilot Study
Role of Cerebral Oximetry in Reducing Postoperative End Organ Dysfunction/Failure After Complex Non-Cardiac Surgery
Validation of Cerebral Non-invasive Monitoring and Prediction of Post-operative Delirium and Outcomes: A Prospective Observational Study
Association of Baseline and Intraoperative rSVO₂ With Postoperative Delirium in Older Noncardiac and Non-neurosurgical Patients: A Prospective Observational Study
Cerebral Regional Oxygen Saturation During TAVI: A Prospective Comparison of Balloon-Expandable and Self-Expanding Valves
Who cites it
77 citing papers in PubMed, 6 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- Silent Brain Infarction, Delirium, and Cognition in Three Invasive Cardiovascular Procedures: a Systematic Review.Neuropsychology review · 2023Pooled it
- Predisposing and Precipitating Factors Associated With Delirium: A Systematic Review.JAMA network open · 2023Pooled it
- The Relationship between the Incidence of Postoperative Cognitive Dysfunction and Intraoperative Regional Cerebral Oxygen Saturation after Cardiovascular Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Reviews in cardiovascular medicine · 2022Pooled it
- Guidelines for the use of cerebral oximetry by near-infrared spectroscopy in cardiovascular anesthesia: a report by the cerebrospinal Division of the Academic Committee of the Japanese Society of Cardiovascular Anesthesiologists (JSCVA).Journal of anesthesia · 2019Guideline
- Risk factors for delirium after on-pump cardiac surgery: a systematic review.Critical care (London, England) · 2015Pooled it
- Cerebral near-infrared spectroscopy monitoring and neurologic outcomes in adult cardiac surgery patients: a systematic review.Anesthesia and analgesia · 2013Pooled it
- The Association between Postoperative Cognitive Dysfunction and Cerebral Oximetry during Geriatric Orthopedic Surgery: A Randomized Controlled Study.BioMed research international · 2021Trial
- Trial
- Intraoperative cerebral oxygenation, oxidative injury, and delirium following cardiac surgery.Free radical biology & medicine · 2017Trial
- Trial
- Association between postoperative arterial blood gas parameters and cognitive dysfunction following coronary artery bypass grafting: a prospective observational study.Irish journal of medical science · 2026Article
- Autonomic Vulnerability Phenotype, Regional Cerebral Oxygen Saturation, and Postoperative Delirium in Elderly Patients Undergoing Non-Cardiac, Non-Neurological Surgery: A Propensity Score-Matched Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Steady-state regional cerebral oxygen saturation integrates multidimensional periprocedural factors and predicts long-term mortality after transcatheter aortic valve implantation.Journal of anesthesia · 2026Article
- Article
- Regional Cerebral Oxygen Saturation and Risk of Delirium: A Systematic Review and Meta-Analysis.Diseases (Basel, Switzerland) · 2025Review
- Role of Cerebral Oximetry in Reducing Postoperative End-Organ Dysfunction After Major Non-Cardiac Surgery: A Randomised Controlled Trial.Clinics and practice · 2025Article
- Development of a Nomogram Model to Predict the Risk of Postoperative Delirium in Cardiac Surgery Patients.Journal of cardiovascular translational research · 2025Article
- Prediction Models for Postoperative Delirium of Cardiovascular Surgery (PODOCVS): Protocol for a Systematic Review.JMIR research protocols · 2025Article
- Characterizing drivers of change in intraoperative cerebral saturation using supervised machine learning.Journal of clinical monitoring and computing · 2025Observational
- The Pathophysiology and Biomarkers of Delirium.Seminars in neurology · 2024Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPostoperative delirium is an important problem in patients undergoing major surgery. Cerebral oximetry is a non-invasive method to detect imbalances in the cerebral oxygen supply/demand-ratio. Low preoperative cerebral oxygen saturation (ScO₂) levels have been associated with postoperative delirium in non-cardiac surgery patients. The present prospective observational study determines the relationship between pre- and intra-operative ScO₂ levels and postoperative delirium in patients undergoing on-pump cardiac surgery.
methodsAfter approval of the local ethical committee and written informed consent, N = 231 patients scheduled for elective/urgent cardiac surgery were enrolled. Delirium was assessed by the confusion-assessment-method for the intensive care unit (CAM-ICU) on the first three days after surgery. ScO₂ was obtained on the day before surgery, immediately before surgery and throughout the surgical procedure. Preoperative cognitive function, demographic, surgery related, and intra- and post-operative physiological data were registered.
resultsPatients with delirium had lower pre- and intra-operative ScO₂ readings, were older, had lower mini-mental-status-examination(MMSE) scores, higher additive EuroScore and lower preoperative haemoglobin-levels. The binary logistic regression identified older age, lower MMSE, neurological or psychiatric disease and lower preoperative ScO₂ as independent predictors of postoperative delirium.
conclusionsThe presented study shows that a low preoperative ScO₂ is associated with postoperative delirium after on-pump cardiac surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.