ReviewExperimental dermatology2011
Mouse models of acute, chemical itch and pain in humans.
Review in Experimental dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- Article
- Kappa opioid receptors in excitatory spinal neurons gate acute pain: evidence from mouse and human.bioRxiv : the preprint server for biology · 2026Article
- Article
- Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High-yield, plant-based production of an antimicrobial peptide with potent activity in a mouse model.Plant biotechnology journal · 2024Article
- Long-term optical imaging of the spinal cord in awake behaving mice.Nature methods · 2024Article
- Itch and Pain Behaviors in Irritant Contact Dermatitis Produced by Sodium Lauryl Sulfate in Mice.International journal of molecular sciences · 2024Article
- Spinal Glycine Receptor Alpha 3 Cells Communicate Sensations of Chemical Itch in Hairy Skin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- SARS-CoV-2 papain-like protease activates nociceptors to drive sneeze and pain.bioRxiv : the preprint server for biology · 2024Article
- Structure-function-guided design of synthetic peptides with anti-infective activity derived from wasp venom.Cell reports. Physical science · 2023Article
- Upregulation of DRG protein TMEM100 facilitates dry-skin-induced pruritus by enhancing TRPA1 channel function.Acta biochimica et biophysica Sinica · 2022Article
- Multiplexed Representation of Itch and Pain and Their Interaction in the Primary Somatosensory Cortex.Experimental neurobiology · 2022Article
- Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain.Science advances · 2022Article
- Punctate Administration of Ficin as a human and animal model of non-histaminergic itch.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Article
- Review
- Pruritus: A Sensory Symptom Generated in Cutaneous Immuno-Neuronal Crosstalk.Frontiers in pharmacology · 2022Review
- MrgprC11Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators.Biochemical pharmacology · 2021Article
- Substance P-expressing Neurons in the Superficial Dorsal Horn of the Mouse Spinal Cord: Insights into Their Functions and their Roles in Synaptic Circuits.Neuroscience · 2020Article
- The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In psychophysical experiments, humans use different verbal responses to pruritic and algesic chemical stimuli to indicate the different qualities of sensation they feel. A major challenge for behavioural models in the mouse of chemical itch and pain in humans is to devise experimental protocols that provide the opportunity for the animal to exhibit a multiplicity of responses as well. One basic criterion is that chemicals that evoke primarily itch or pain in humans should elicit different types of responses when applied in the same way to the mouse. Meeting this criterion is complicated by the fact that the type of behavioural responses exhibited by the mouse depends in part on the site of chemical application such as the nape of the neck that evokes only scratching with the hind paw versus the hind limb that elicits licking and biting. Here, we review to what extent mice behaviourally differentiate chemicals that elicit itch versus pain in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.