Evidence map›Paper›PMID 21929642›Full record

ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2011

Delayed graft function in the kidney transplant.

A Siedlecki, W Irish, D C Brennan

4 registry-linked trialsAbstract readReview
In one paragraph

Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 346 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
346citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03663543 phase1 / phase2active not recruitingnot on this mapstarted 2016, after this paper: background citation

The Use of Peri-Operative Intravenous Estrogen for the Mitigation of Ischemia Reperfusion Injury in the Setting of Renal Transplantation

TypeinterventionalSponsorUniversity of PennsylvaniaRan2016 to 2027Enrolled30ConditionsIschemia Reperfusion InjuryArmsConjugated Estrogen, Normal saline
NCT03846869 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Major Cations Targeted Fluid Therapy In Renal Transplantation.

TypeinterventionalSponsorMansoura UniversityRan2019 to 2021Enrolled50ConditionsRenal Transplant FailureArmsmajor cations
NCT07678073 narecruitingnot on this mapstarted 2026, after this paper: background citation

Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation: A Prospective Controlled Study

TypeinterventionalSponsorUniversity of GaziantepRan2026 to 2026Enrolled68ConditionsKidney Disease, End-Stage, Kidney Transplant, Kidney, Kidney DiseaseArmsSevoflurane General Anesthesia, Bupivacaine and Morphine for Combined Spinal-Epidural Anesthesia
NCT07726134 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot Randomized, Surgeon-blinded, Trial of Intraoperative Furosemide Versus Mannitol Among Deceased Donor Kidney Transplant Recipients

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2026 to 2028Enrolled160ConditionsDelayed Graft Function, Kidney TransplantationArmsFurosemide, Mannitol
3 · Its place in the literature

Who cites it

346 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Trial
  7. Article
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  10. Urinary UDP-sugars provide actionable prediction of acute kidney injury in cardiac surgery patients.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  11. Article
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  14. Review
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  17. Observational
  18. Article
  19. Review
  20. Intraorgan and targeted nanodelivery in organ transplantation of nonhuman primates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article

286 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

A SiedleckiNephrology Division, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. andrew.siedlecki@gmail.com
W Irish
D C Brennan

Funding

Washington University Center for Kidney Disease ResearchP30DK079333 · NIDDK · WASHINGTON UNIVERSITY · PI HAMMERMAN, MARC RANDALL · 2007 to 2011
$5.1M
THE ROLE OF REGULATOR OF G-PROTEIN SIGNALING 4 IN ACUTE KIDNEY INJURYK08DK089002 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SIEDLECKI, ANDREW MICHAEL · 2011 to 2015
$795k
NIDDK NIH HHS K08 DK089002NIDDK NIH HHS K08DK089002NIDDK NIH HHS P30 DK079333NIDDK NIH HHS P30-DK079333
6 · The paper itself

Abstract

Acute kidney injury occurs with kidney transplantation and too frequently progresses to the clinical diagnosis of delayed graft function (DGF). Poor kidney function in the first week of graft life is detrimental to the longevity of the allograft. Challenges to understand the root cause of DGF include several pathologic contributors derived from the donor (ischemic injury, inflammatory signaling) and recipient (reperfusion injury, the innate immune response and the adaptive immune response). Progressive demand for renal allografts has generated new organ categories that continue to carry high risk for DGF for deceased donor organ transplantation. New therapies seek to subdue the inflammatory response in organs with high likelihood to benefit from intervention. Future success in suppressing the development of DGF will require a concerted effort to anticipate and treat tissue injury throughout the arc of the transplantation process.

Indexed as

AnticoagulantsBrain DeathDelayed Graft FunctionGraft SurvivalHumansImmunosuppression TherapyIschemic PreconditioningKidney TransplantationOrgan PreservationPerfusionReperfusion InjuryRisk FactorsThrombosisTissue DonorsWarm IschemiaAnticoagulants

Identifiers

PMID21929642
PMCPMC3280444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.