ArticleVeterinary ophthalmology2011
Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome in PMEL17 (Silver) mutant ponies: five cases.
Article in Veterinary ophthalmology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 49 citations in OpenAlex.
- Cognitive performance and variability in dromedary camels: insights from a comparative psychometric approach.BMC veterinary research · 2025Article
- A survey of ocular pathology in Warmblood horses in South Africa.Equine veterinary journal · 2025Article
- The Youngest, the Heaviest and/or the Darkest? Selection Potentialities and Determinants of Leadership in Canarian Dromedary Camels.Animals : an open access journal from MDPI · 2021Article
- Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins.Molecules (Basel, Switzerland) · 2021Article
- A copy number variant is associated with a spectrum of pigmentation patterns in the rock pigeon (Columba livia).PLoS genetics · 2020Article
- The refractive state of the eye in Icelandic horses with the Silver mutation.BMC veterinary research · 2017Article
- Distribution of coat-color-associated alleles in the domestic horse population and Przewalski's horse.Journal of applied genetics · 2016Article
- Equine multiple congenital ocular anomalies and silver coat colour result from the pleiotropic effects of mutant PMEL.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo describe the clinical phenotype and genetics of equine Multiple Congenital Ocular Anomalies (MCOA) syndrome in PMEL17 (Silver) mutant ponies. ANIMALS STUDIED: Five presumably unrelated ponies. PROCEDURES: The ponies were examined under field conditions in their barn by slit lamp biomicroscopy, indirect ophthalmoscopy, and applanation tonometry. Blood was collected and genomic DNA extracted for MCOA genotyping using the PMEL17ex11 marker.
resultsOne pony solely presented with temporal ciliary body cysts, suggestive of the less severe Cyst phenotype of MCOA; the animal was heterozygous at the MCOA locus. Multiple bilateral anterior segment anomalies were identified in four ponies, consistent with the more severe MCOA phenotype characterized by cornea globosa, iris hypoplasia, encircling granula iridica along the pupillary ruff, and cataracts. These animals were homozygous for the mutant MCOA allele. Four of the ponies had a silver dapple or chocolate coat color with white or flaxen manes and tails. Silver dappling was masked by the palomino coloring of a 5th pony that was homozygous at the MCOA locus.
conclusionsThe MCOA syndrome can be seen in ponies. The results of both clinical evaluation and genotyping resembled the previously described MCOA of both Rocky Mountain and Kentucky Mountain Saddle horses.
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