ArticleSeminars in dialysis
Dialysis cannot be dosed.
Article in Seminars in dialysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients.Journal of the American Society of Nephrology : JASN · 2017Trial
- Intradialytic optical assessment of C-mannosyl tryptophan removal using spent dialysate.Scientific reports · 2025Article
- Increasing the Removal of Large Solutes by Kidney Replacement Therapy.Journal of the American Society of Nephrology : JASN · 2025Review
- Residual Kidney Function in Hemodialysis: Its Importance and Contribution to Improved Patient Outcomes.Toxins · 2024Review
- Time-averaged concentration estimation of uraemic toxins with different removal kinetics: a novel approach based on intradialytic spent dialysate measurements.Clinical kidney journal · 2023Article
- Precision medicine in transplantation and hemodialysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Article
- Association of trimethylamineRenal failure · 2020Article
- Plasma pseudouridine levels reflect body size in children on hemodialysis.Pediatric nephrology (Berlin, Germany) · 2020Article
- Twice-Weekly Hemodialysis and Clinical Outcomes in the China Dialysis Outcomes and Practice Patterns Study.Kidney international reports · 2018Article
- Kt/Vurea and Nonurea Small Solute Levels in the Hemodialysis Study.Journal of the American Society of Nephrology : JASN · 2016Article
- New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma.Scientific reports · 2016Article
- Hemodialysis Prescription for Incident Patients: Twice Seems Nice, But Is It Incremental?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016Article
- Once upon a time in dialysis: the last days of Kt/V?Kidney international · 2015Review
- Article
- Approaches to uremia.Journal of the American Society of Nephrology : JASN · 2014Review
- Two-times weekly hemodialysis in China: frequency, associated patient and treatment characteristics and Quality of Life in the China Dialysis Outcomes and Practice Patterns study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Article
- Numerous protein-bound solutes are cleared by the kidney with high efficiency.Kidney international · 2013Article
- Searching for uremic toxins.Clinical journal of the American Society of Nephrology : CJASN · 2013Review
- Does the adequacy parameter Kt/V(urea) reflect uremic toxin concentrations in hemodialysis patients?PloS one · 2013Article
- Home haemodialysis and uraemic toxin removal: does a happy marriage exist?Nature reviews. Nephrology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Adequate dialysis is difficult to define because we have not identified the toxic solutes that contribute most to uremic illness. Dialysis prescriptions therefore cannot be adjusted to control the levels of these solutes. The current solution to this problem is to define an adequate dose of dialysis on the basis of fraction of urea removed from the body. This has provided a practical guide to treatment as the dialysis population has grown over the past 25 years. Indeed, a lower limit to Kt/V(urea) (or the related urea reduction ratio) is now established as a quality indicator by the Centers for Medicare and Medicaid for chronic hemodialysis patients in the United States. For the present, this urea-based standard provides a useful tool to avoid grossly inadequate dialysis. Dialysis dosing, however, based on measurement of a single, relatively nontoxic solute can provide only a very limited guide toward improved treatment. Prescriptions which have similar effects on the index solute can have widely different effects on other solutes. The dose concept discourages attempts to increase the removal of such solutes independent of the index solute. The dose concept further assumes that important solutes are produced at a constant rate relative to body size, and discourages attempts to augment dialysis treatment by reducing solute production. Identification of toxic solutes would provide a more rational basis for the prescription of dialysis and ultimately for improved treatment of patients with renal failure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.