ArticleNeurogastroenterology and motility2011
High resolution manometry patterns distinguish acid sensitivity in non-cardiac chest pain.
Article in Neurogastroenterology and motility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry.Journal of neurogastroenterology and motility · 2018Article
- What Is the Impact of High-Resolution Manometry in the Functional Diagnostic Workup of Gastroesophageal Reflux Disease?Visceral medicine · 2018Review
- Elevated intrabolus pressure identifies obstructive processes when integrated relaxation pressure is normal on esophageal high-resolution manometry.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Comparison of motor diagnoses by Chicago Classification versions 2.0 and 3.0 on esophageal high-resolution manometry.Neurogastroenterology and motility · 2017Observational
- Impact of symptom burden and health-related quality of life (HRQOL) on esophageal motor diagnoses.Neurogastroenterology and motility · 2017Article
- Prevalence, characteristics, and treatment outcomes of reflux hypersensitivity detected on pH-impedance monitoring.Neurogastroenterology and motility · 2016Article
- GERD phenotypes from pH-impedance monitoring predict symptomatic outcomes on prospective evaluation.Neurogastroenterology and motility · 2016Observational
- Achalasia symptom response after Heller myotomy segregated by high-resolution manometry subtypes.Journal of gastroenterology · 2016Observational
- Clinical Significance of Esophageal Hypertensive Peristaltic Contractions on High-resolution Manometry(Neurogastroenterol Motil 2015;27:229-236).Journal of neurogastroenterology and motility · 2015Article
- Parameters on esophageal pH-impedance monitoring that predict outcomes of patients with gastroesophageal reflux disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
- Exaggerated smooth muscle contraction segments on esophageal high-resolution manometry: prevalence and clinical relevance.Neurogastroenterology and motility · 2015Article
- Acid-based parameters on pH-impedance testing predict symptom improvement with medical management better than impedance parameters.The American journal of gastroenterology · 2014Article
- Multiple rapid swallow responses segregate achalasia subtypes on high-resolution manometry.Neurogastroenterology and motility · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHigh resolution manometry (HRM) has demonstrated two distinct smooth muscle contraction segments in the esophageal body; changes in these segments typify certain esophageal disorders. We investigated segmental characteristics in subgroups of non-cardiac chest pain (NCCP).
methods32 NCCP subjects were segregated into a GERD group (ambulatory pH testing off antisecretory therapy showing elevated total acid exposure time, AET≥4.0% and positive symptom association probability, SAP) and an acid sensitive group (normal AET and positive SAP). HRM Clouse plots were analyzed; smooth muscle segment lengths, pressure amplitude peaks were measured for segment 2 and segment 3 (proximal and distal smooth muscle segments). Pressure volumes were determined in mmHg cm(-1) s(-1) for each peristaltic segment, and ratios of segment 3:segment 2 calculated. Values were compared to a cohort of 14 normal controls. KEY
resultsA distinctive shift in peak contraction amplitude to segment 3 was evident in the acid sensitive group (segment 2, 100.03±11.06mmHg, segment 3, 145.23± 10.29mmHg, P=0.006). Pressure volumes were similarly shifted to segment 3 (segment 2: 855.3 ± 135.1 mmHg cm(-1) s(-1) , segment 3: 2115.2±218.6 mmHg cm(-1) s(-1) , P<0.005). In contrast, peak amplitude and pressure volume were near equal in the two segments in GERD and control groups. A threshold segment 3:segment 2 pressure volume ratio of 1.9 had the best performance characteristic for segregating acid sensitivity subjects from all GERD and control subjects. CONCLUSIONS & INFERENCES: Shift in contractile vigor to the third peristaltic segment may be seen in acid sensitive subjects. HRM characteristics of smooth muscle contraction segments are of value in making this determination.
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