ArticlePhysical review letters2011
Splitting probabilities as a test of reaction coordinate choice in single-molecule experiments.
Article in Physical review letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Evidence and quantification of memory effects in competitive first-passage events.Science advances · 2025Article
- Stochastic Model of Solvent Exchange in the First Coordination Shell of Aqua Ions.Journal of chemical theory and computation · 2022Article
- A Bayesian approach to extracting free-energy profiles from cryo-electron microscopy experiments.Scientific reports · 2021Article
- Exploring the sequence fitness landscape of a bridge between protein folds.PLoS computational biology · 2020Article
- Molecular free energy profiles from force spectroscopy experiments by inversion of observed committors.The Journal of chemical physics · 2019Article
- Direct measurement of sequence-dependent transition path times and conformational diffusion in DNA duplex formation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- -1 Programmed Ribosomal Frameshifting as a Force-Dependent Process.Progress in molecular biology and translational science · 2016Review
- Reconstructing folding energy landscapes from splitting probability analysis of single-molecule trajectories.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Markov state models provide insights into dynamic modulation of protein function.Accounts of chemical research · 2015Review
- Optimal reaction coordinate as a biomarker for the dynamics of recovery from kidney transplant.PLoS computational biology · 2014Article
- Reconstructing folding energy landscapes by single-molecule force spectroscopy.Annual review of biophysics · 2014Review
- Transition pathway and its free-energy profile: a protocol for protein folding simulations.International journal of molecular sciences · 2013Article
- To milliseconds and beyond: challenges in the simulation of protein folding.Current opinion in structural biology · 2013Review
- Characterization of a dynamic string method for the construction of transition pathways in molecular reactions.The journal of physical chemistry. B · 2012Article
- The molten globule state is unusually deformable under mechanical force.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
To explain the observed dynamics in equilibrium single-molecule measurements of biomolecules, the experimental observable is often chosen as a putative reaction coordinate along which kinetic behavior is presumed to be governed by diffusive dynamics. Here, we invoke the splitting probability as a test of the suitability of such a proposed reaction coordinate. Comparison of the observed splitting probability with that computed from the kinetic model provides a simple test to reject poor reaction coordinates. We demonstrate this test for a force spectroscopy measurement of a DNA hairpin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.