Evidence map›Paper›PMID 21928661›Full record

ArticleMedical physics2011

Equating quantitative emphysema measurements on different CT image reconstructions.

Seth T Bartel, Andrew J Bierhals, Thomas K Pilgram, Cheng Hong, Kenneth B Schechtman, Susan H Conradi, David S Gierada

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Medical physics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Lung Mass in Smokers.Academic radiology · 2017
    Article
  8. Emphysema Quantification on Cardiac CT Scans Using Hidden Markov Measure Field Model: The MESA Lung Study.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2016
    Article
  9. Observational
  10. DERIVATION OF A TEST STATISTIC FOR EMPHYSEMA QUANTIFICATION.Proceedings. IEEE International Symposium on Biomedical Imaging · 2016
    Article
  11. Observational
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seth T BartelMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Andrew J Bierhals
Thomas K Pilgram
Cheng Hong
Kenneth B Schechtman
Susan H Conradi
David S Gierada

Funding

Registry And Data AnalysisP50HL084922 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2007 to 2011
$14.0M
HE3 MR Diffusion &Low Dose CT Quantitation of EmphysemaR01HL072369 · NHLBI · WASHINGTON UNIVERSITY · PI GIERADA, DAVID S · 2002 to 2005
$1.5M
NHLBI NIH HHS P50 HL084922NHLBI NIH HHS R01 HL072369NHLBI NIH HHS R01 HL72369
6 · The paper itself

Abstract

purposeTo mathematically model the relationship between CT measurements of emphysema obtained from images reconstructed using different section thicknesses and kernels and to evaluate the accuracy of the models for converting measurements to those of a reference reconstruction.

methodsCT raw data from the lung cancer screening examinations of 138 heavy smokers were reconstructed at 15 different combinations of section thickness and kernel. An emphysema index was quantified as the percentage of the lung with attenuation below -950 HU (EI950). Linear, quadratic, and power functions were used to model the relationship between EI950 values obtained with a reference 1 mm, medium smooth kernel reconstruction and values from each of the other 14 reconstructions. Preferred models were selected using the corrected Akaike information criterion (AICc), coefficients of determination (R2), and residuals (conversion errors), and cross-validated by a jackknife approach using the leave-one-out method.

resultsThe preferred models were power functions, with model R2 values ranging from 0.949 to 0.998. The errors in converting EI950 measurements from other reconstructions to the 1 mm, medium smooth kernel reconstruction in leave-one-out testing were less than 3.0 index percentage points for all reconstructions, and less than 1.0 index percentage point for five reconstructions. Conversion errors were related in part to image noise, emphysema distribution, and attenuation histogram parameters. Conversion inaccuracy related to increased kernel sharpness tended to be reduced by increased section thickness.

conclusionsImage reconstruction-related differences in quantitative emphysema measurements were successfully modeled using power functions.

Indexed as

HumansImage Processing, Computer-AssistedModels, StatisticalPulmonary EmphysemaReproducibility of ResultsTomography, X-Ray Computed

Identifiers

PMID21928661
PMCPMC3165435

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.