Evidence map›Paper›PMID 21928247›Full record

ReviewThe International journal of biological markers

-The advancement of biomarker-based diagnostic tools for ovarian, breast, and pancreatic cancer through the use of urine as an analytical biofluid.

Brian M Nolen, Anna E Lokshin

Abstract readReview
In one paragraph

Review in The International journal of biological markers. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Diagnosis of prostate cancer via nanotechnological approach.International journal of nanomedicine · 2015
    Review
  7. Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brian M NolenUniversity of Pittsburgh Cancer Institute, Pittsburgh, PA - USA and Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA - USA.
Anna E Lokshin

Funding

Urine and Serum Biomarkers for Screening and Diagnosis of Ovarian CancerR01CA108990 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOKSHIN, ANNA E. · 2005 to 2014
$5.3M
Multiplexed Serum Biomarkers for Pancreatic CancerU01CA117452 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOKSHIN, ANNA E. · 2005 to 2009
$2.7M
Identification of Early Markers for Ovarian CancerR01CA098642 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOKSHIN, ANNA E. · 2003 to 2006
$1.3M
Development of a multimarker urine-based test for early diagnosis and screening oR21CA143736 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOKSHIN, ANNA E. · 2010 to 2011
$357k
NCI NIH HHS R01 CA098642NCI NIH HHS R01 CA108990NCI NIH HHS R21 CA143736NCI NIH HHS U01 CA117452
6 · The paper itself

Abstract

Despite considerable advancements, the development of effective cancer screening tools based on serum biomarker measurements has thus far failed to achieve a meaningful clinical impact. The incremental progress observed over the course of serum biomarker development suggests that further refinements based on novel approaches may yet result in a breakthrough. The use of urine as an analytical biofluid for biomarker development may represent such an approach. The unique characteristics of urine including a high level of stability, ease of sampling, and an inactive and low-complexity testing matrix offer several potential advantages over the use of serum. A number of recent reports have demonstrated the utility of urine in the identification of novel cancer biomarkers and also the improved performance of biomarkers previously evaluated in serum. In this review, advancements related to the use of urine biomarkers within the settings of ovarian, breast, and pancreatic cancer are presented and discussed. Findings regarding the identification of specific urine biomarkers for each disease are highlighted along with comparative analyses of urine and serum biomarkers as diagnostic tools.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorBreast NeoplasmsDiagnostic Tests, RoutineEarly Detection of CancerFemaleHumansMaleMiddle AgedOvarian NeoplasmsPancreatic NeoplasmsYoung AdultBiomarkers, Tumor

Identifiers

PMID21928247
PMCPMC4556600

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.