Trial reportHernia : the journal of hernias and abdominal wall surgery2012
Prophylactic antibiotic use in elective inguinal hernioplasty in a trauma center.
Trial report in Hernia : the journal of hernias and abdominal wall surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 5 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- The role of prophylactic antibiotics in elective inguinal tension-free hernia repair: A systematic review and meta-analysis.International wound journal · 2023Pooled it
- Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair.The Cochrane database of systematic reviews · 2020Pooled it
- Network meta-analysis of antibiotic prophylaxis for prevention of surgical-site infection after groin hernia surgery.The British journal of surgery · 2017Pooled it
- Antibiotic prophylaxis for open mesh repair of groin hernia: systematic review and meta-analysis.Hernia : the journal of hernias and abdominal wall surgery · 2016Pooled it
- Antibiotic prophylaxis for hernia repair.The Cochrane database of systematic reviews · 2012Pooled it
- Comments on the new groin hernia guidelines: What has changed? What has remained unanswered?Turkish journal of surgery · 2018Review
- The effectiveness of i.v. cefuroxime prophylaxis of surgical site infection after elective inguinal hernia repair with mesh: A retrospective observational study.European journal of clinical pharmacology · 2016Observational
- Antibiotic prophylaxis in open inguinal hernia repair: a literature review and summary of current knowledge.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2016Review
- Hernia, mesh, and topical antibiotics, especially gentamycin: seeking the evidence for the perfect outcome….Frontiers in surgery · 2014Review
- Use of antibiotic prophylaxis in elective inguinal hernia repair in adults in London and south-east England: a cross-sectional survey.Hernia : the journal of hernias and abdominal wall surgery · 2013Article
- The Role of Antibiotic Prophylaxis in Lichtenstein Repair of Primary Inguinal Hernia: A Prospective Double-Blind Randomized Placebo-Controlled Trial.Nigerian journal of surgery : official publication of the Nigerian Surgical Research SocietyArticle
- Comparison between outcome of single dose of prophylactic antibiotic versus postoperative antibiotic in inguinal hernia surgery.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn this double-blind prospective randomized trial, our objective was to investigate the effect of antibiotic prophylaxis in patients undergoing elective inguinal hernia surgery with mesh repair in a large-volume tertiary referral trauma center.
methodsEligible patients were assigned randomly to either an antibiotic prophylaxis group or a control group. Patients in the prophylaxis group were given 1 g cefazolin by IV bolus injection whereas the placebo control group received an equal volume of sterile saline preoperatively. A Lichtenstein repair was done in all cases. The patients were examined for surgical site infection (SSI) and other postoperative local complications before discharge, and reexamined 3, 5, 7, and 30 days after discharge.
resultsGroups were well matched for age, sex, coexisting diseases, ASA scores, type of hernia, type of anesthesia, duration of surgery. Incidence of infection was 7% in the control group (7/100) and 5% in the prophylaxis group (5/100) (P = 0.38). All the infections were superficial and responded well to drainage and proper antibiotic therapy. All other postoperative complications were similar in the two groups.
conclusionsIn our settings antibiotic prophylaxis has no significant effect on the incidence of SSI in elective repair of inguinal hernias with mesh. The most effective way to reduce the incidence of infection in prosthetic repair may be a specific center for treatment of abdominal wall hernias.
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