ArticleBiogerontology2012
Extension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat.
Article in Biogerontology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Hsian-Tsao (Frontiers in nutrition · 2022Article
- Phytochemical Study and In Vitro Screening Focusing on the Anti-Aging Features of Various Plants of the Greek Flora.Antioxidants (Basel, Switzerland) · 2021Article
- Anise HyssopFrontiers in physiology · 2020Article
- Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster.International journal of molecular sciences · 2018Article
- Current Perspective in the Discovery of Anti-aging Agents from Natural Products.Natural products and bioprospecting · 2017Review
- Effects of Abies sibirica terpenes on cancer- and aging-associated pathways in human cells.Oncotarget · 2016Article
- Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster.Archives of insect biochemistry and physiology · 2016Article
- Healthspan Pharmacology.Rejuvenation research · 2015Article
- Green tea polyphenols extend the lifespan of male drosophila melanogaster while impairing reproductive fitness.Journal of medicinal food · 2014Article
- Changes in the expression of four heat shock proteins during the aging process in Brachionus calyciflorus (rotifera).Cell stress & chaperones · 2014Article
- Iron absorption in Drosophila melanogaster.Nutrients · 2013Review
- Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance.Longevity & healthspan · 2013Article
- Pharmacological lifespan extension of invertebrates.Ageing research reviews · 2013Review
- Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction.PloS one · 2013Article
- Nutraceutical interventions for promoting healthy aging in invertebrate models.Oxidative medicine and cellular longevity · 2012Review
- The Yang-Tonifying Herbal Medicine Cynomorium songaricum Extends Lifespan and Delays Aging in Drosophila.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Rosa damascena, or Damask rose, is a rose hybrid commonly harvested for rose oil used in perfumery and for rose water used to flavor food. The petal extract of R. damascena was recently found to decrease Drosophila melanogaster mortality without impairing reproductive fitness or metabolic rate. Here, we report that R. damascena extended both mean and maximum lifespan of the fly. The extract also protected against oxidative stress in flies, predominantly in females. However, it did not alter mitochondrial respiration or content, superoxide production, or the major antioxidant defenses, superoxide dismutase and catalase. The extract increased survival in both sexes when exposed to reduced iron, though surprisingly, it sensitized both sexes to heat stress (survival at 37°C), and appeared to down-regulate the major heat shock protein HSP70 and the small mitochondrial heat shock protein HSP22, at 25°C and after heat shock (4 h at 37°C). We hypothesize that R. damascena extends lifespan by protecting against iron, which concomitantly leads to decreased HSP expression and compromising heat tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.