ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2012
Late-type vitamin K deficiency bleeding: experience from 120 patients.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 29 citations in OpenAlex.
- Genetic Polymorphism ofClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Trial
- Large intracerebral hemorrhage in the setting of vitamin K prophylaxis refusal.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Vitamin K deficiency manifesting as generalised skin bleed in infant.Sudanese journal of paediatrics · 2025Article
- Spontaneous intracranial hemorrhage presenting in a patient with vitamin K deficiency and COVID-19: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Refusal of Intramuscular Vitamin K by Parents of Newborns: A Review.Hospital pediatrics · 2020Review
- Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding.International journal of pharmaceutics · 2018Article
- Vitamin K deficiency: a case report and review of current guidelines.Italian journal of pediatrics · 2018Review
- Estimated costs for treatment and prophylaxis of newborn vitamin K deficiency bleeding in Tashkent, Uzbekistan.Nagoya journal of medical science · 2018Article
- Negative Impact of Prolonged Antibiotics or Persistent Diarrhea on Vitamin K1 Levels in 2-24 Weeks aged Egyptian Infants.Mediterranean journal of hematology and infectious diseases · 2018Article
- A historic study that opened a new chapter in nutritional science.Acta pharmacologica Sinica · 2016Article
- Intracranial hemorrhage in infants as a serious, and preventable consequence of late form of vitamin K deficiency: a selfie picture of Turkey, strategies for tomorrow.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Vitamin k deficiency bleeding presenting as nodular purpura in infancy: a rare and life-threatening entity.Indian journal of dermatology · 2013Article
- Late vitamin K deficiency bleeding in infants: five-year prospective study.Jornal de pediatriaArticle
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDeficiency of vitamin K predisposes to early, classic, or late vitamin K deficiency bleeding (VKDB), of which late VKDB may be associated with serious and life-threatening intracranial bleeding. Late VKDB is characterized with intracranial bleeding in infants aged 2-24 weeks due to severe vitamin K deficiency, occurring primarily in exclusively breast-fed infants. Late VKDB is still an important cause of mortality and morbidity in developing countries. MATERIALS AND
methodsWe presented 120 cases of late VKDB, which were evaluated at Erciyes University Medical Faculty Hospital between June 1990 and June 2006.
resultsSigns and symptoms of the patients were bulging fontanels (70%); irritabilities (50%); convulsions (49%); bleeding and ecchymosis (47%); feeding intolerance, poor sucking, and vomiting (46%); diarrhea (34%); jaundice (11%); and pallor (9%), and among these infants, 21% received medication before the diagnosis (10%, antibiotics; 3%, simethicone; 4%, paracetamol; and 4%, phenobarbital). Intracranial hemorrhage in 88 (73%) patients has been observed. The hemorrhage was subdural in 34 (28%) cases, intracerebral in 28 (23%), subarachnoid in 17 (14%), intraventricular in 9 (8%), intracerebral and subdural in 12 (10%), subdural and subarachnoid in 6 (5%), and combination of intracerebral, subdural, and intraventricular in 14 (12%), and the mortality rate was 31%.
conclusionAlthough late VKDB leads to significant morbidity and mortality, it can be avoided by providing vitamin K prophylaxis to all newborns. Administration of vitamin K (1 mg) at birth can prevent intracranial bleeding and other hemorrhagic manifestations.
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